e-Drug3D

832

cas 117976-89-3

CLASS

METABOLISM
ANTIULCERATIVE
ANTISECRETORY (GASTRIC ACID)
PROTON-PUMP INHIBITOR (PPI)
H+, K+ ATPASE INHIBITOR

ROUTE (list)

ORAL

PK parameters

F 52 PERCENT
Tmax 3.5 HOUR
VD 14.3 LITER (65 KILOGRAM)
Cl 15.6 LITER / HOUR (65 KILOGRAM)
PPB 96.3 PERCENT
t1/2 1.5 HOUR

TARGET POTASSIUM-TRANSPORTING ATPASE

PDB
3PGL (CRYSTAL STRUCTURE OF HUMAN SMALL C-TERMINAL DOMAIN PHOSPHATASE 1 (SCP1) BOUND TO RABEPRAZOLE)

Ligand code = RZX (link to the list of PDB complexes)

Download experimental 3D coordinates of RZX with added hydrogens

MW 359.45
NB_atoms 25
XLogP 2.99
PSA 74.093
NB_HD 1
NB_HA 6
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 020973 (label) INN (RABEPRAZOLE SODIUM) ACIPHEX (WAYLIS THERAP) APPROVAL= AP YEAR= 1999
NDA 021456 (label) INN (RABEPRAZOLE SODIUM) ACIPHEX (EISAI MEDCL RES) APPROVAL= AP YEAR= 2002 NEWAPPLICATION
NDA 076822 (label) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 076885 (label) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 076824 (pdf not found) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (DR REDDYS) APPROVAL= AP YEAR= 2013
NDA 078964 (label) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 090678 (label) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (LANNETT CO INC) APPROVAL= AP YEAR= 2013
NDA 202376 (pdf not found) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (TORRENT) APPROVAL= AP YEAR= 2013
NDA 204736 (label) INN (RABEPRAZOLE SODIUM) ACIPHEX SPRINKLE (AYTU) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 204179 (pdf not found) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015
NDA 204237 (pdf not found) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (RUBICON RESEARCH) APPROVAL= AP YEAR= 2015
NDA 205761 (pdf not found) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017
NDA 208644 (pdf not found) INN (RABEPRAZOLE SODIUM) RABEPRAZOLE SODIUM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2018