e-Drug3D

831

cas 154598-52-4

CLASS

ANTIINFECTIVES
ANTIVIRAL
ANTI-HIV
HIV-1 NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR

ROUTE (list)

ORAL

PK parameters

Tmax 5 HOUR
PPB 99.6 PERCENT
t1/2 64 HOUR

TARGET HIV-1 REVERSE TRANSCRIPTASE

PDB
6BSJ (STRUCTURE OF HIV-1 RT COMPLEXED WITH AN RNA, DNA HYBRID SEQUENCE NON-PREFERRED FOR RNA HYDROLYSIS)

Ligand code = EFZ (link to the list of PDB complexes)

Download experimental 3D coordinates of EFZ with added hydrogens

MW 315.67
NB_atoms 21
XLogP 4.07
PSA 40.644
NB_HD 1
NB_HA 3
fsp3 0.36
Lipinski(0=no;1=yes) 1

FDA
NDA 020972 (label) INN (EFAVIRENZ) SUSTIVA (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 021360 (label) INN (EFAVIRENZ) SUSTIVA (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021937 (label) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) ATRIPLA (GILEAD SCIENCES) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 021943 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; EFAVIRENZ) LAMIVUDINE; ZIDOVUDINE (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2006
NDA 077916 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (CIPLA LIMITED) APPROVAL= TA YEAR= 2006
NDA 022096 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; EFAVIRENZ) LAMIVUDINE; ZIDOVUDINE; EFAVIRENZ (STRIDES ACROLAB) APPROVAL= TA YEAR= 2007
NDA 022097 (pdf not found) INN (STAVUDINE ; LAMIVUDINE ; EFAVIRENZ) STAVUDINE; LAMIVUDINE; EFAVIRENZ (STRIDES ACROLAB) APPROVAL= TA YEAR= 2007
NDA 078958 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (EMCURE PHARMA) APPROVAL= TA YEAR= 2007
NDA 078883 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (MATRIX LABS) APPROVAL= TA YEAR= 2008
NDA 022297 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2008 OBSOLETE
NDA 022461 (label) INN (EFAVIRENZ) EFAVIRENZ (MATRIX LABS LTD) APPROVAL= TA YEAR= 2009
NDA 090155 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (CIPLA LIMITED) APPROVAL= TA YEAR= 2009
NDA 090437 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ; EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE (MATRIX LABS LTD) APPROVAL= TA YEAR= 2009
NDA 022420 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ 200MG SCORED TABLETS (STRIDES ARCOLAB LTD) APPROVAL= TA YEAR= 2010
NDA 202042 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (MICRO LABS LTD) APPROVAL= TA YEAR= 2012
NDA 091593 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ; EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE (CIPLA LIMITED) APPROVAL= TA YEAR= 2012
NDA 202301 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (MICRO LABS LTD) APPROVAL= TA YEAR= 2012
NDA 202990 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (PAR FORMULATIONS PRIVATE LTD) APPROVAL= TA YEAR= 2012
NDA 204568 (pdf not found) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, LAMIVUDINE, AND TENOFOVIR DISOPROXIL FUMARATE (CIPLA) APPROVAL= TA YEAR= 2013
NDA 205861 (pdf not found) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ; LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE (MACLEODS PHARMS LTD) APPROVAL= TA YEAR= 2014
NDA 206040 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; EFAVIRENZ) LAMIVUDINE; ZIDOVUDINE; EFAVIRENZ (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 206584 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ; EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE (EMCURE PHARMS LTD) APPROVAL= TA YEAR= 2015 OBSOLETE
NDA 091175 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (TEVA PHARMS USA) APPROVAL= TA YEAR= 2015
NDA 091471 (label) INN (EFAVIRENZ) EFAVIRENZ (MYLAN) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 078064 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017
NDA 204119 (pdf not found) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, LAMIVUDINE, AND TENOFOVIR DISOPROXIL FUMARATE (HETERO DRUGS LTD) APPROVAL= TA YEAR= 2017
NDA 207895 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (PHARMACARE LTD) APPROVAL= TA YEAR= 2017
NDA 077673 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018
NDA 078886 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (HETERO LABS LTD III) APPROVAL= AP YEAR= 2018
NDA 022142 (label) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) SYMFI (MYLAN LABS LTD) APPROVAL= AP YEAR= 2018
NDA 091215 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2018
NDA 022343 (label) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 203041 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2018
NDA 204869 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2018
NDA 205322 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 204766 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (CIPLA) APPROVAL= AP YEAR= 2018
NDA 208255 (label) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) SYMFI LO (MYLAN) APPROVAL= AP YEAR= 2018
NDA 205389 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (MICRO LABS LTD INDIA) APPROVAL= TA YEAR= 2018
NDA 206894 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE (CIPLA) APPROVAL= AP YEAR= 2019
NDA 210649 (label) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212786 (pdf not found) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE (LAURUS) APPROVAL= AP YEAR= 2020
NDA 213038 (pdf not found) INN (EFAVIRENZ ; LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, LAMIVUDINE AND TENOFOVIR DISOPROXIL FUMARATE (LAURUS) APPROVAL= AP YEAR= 2020
NDA 078509 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (STRIDES PHARMA) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 204287 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2021
NDA 213541 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE (LAURUS) APPROVAL= AP YEAR= 2021
NDA 203053 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ, EMTRICITABINE, AND TENOFOVIR DISOPROXIL FUMARATE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2022
NDA 201802 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ; EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE (CHARTWELL RX) APPROVAL= AP YEAR= 2023
NDA 091579 (pdf not found) INN (EFAVIRENZ) EFAVIRENZ (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 213509 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR ALAFENAMIDE) EFAVIRENZ, EMTRICITABINE AND TENOFOVIR ALAFENAMIDE (MYLAN) APPROVAL= TA YEAR= 2024
NDA 209061 (pdf not found) INN (EFAVIRENZ ; EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE) EFAVIRENZ; EMTRICITABINE; TENOFOVIR DISOPROXIL FUMARATE (MYLAN) APPROVAL= AP YEAR= 2024 DISCONTINUED