e-Drug3D

827

GEMIFLOXACIN

DISCONTINUED

INN
GEMIFLOXACIN

cas 175463-14-6

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
FLUOROQUINOLONE CLASS OF ANTIBIOTICS

ROUTE (list)

ORAL

ATC code

J01MA15

PK parameters

F 71 PERCENT
Tmax 1.25 HOUR
VD 271 LITER (65 KILOGRAM)
Cl 26.8 LITER / HOUR (EQN)
PPB 65 PERCENT
t1/2 7 HOUR

Solubility

FREELY SOLUBLE AT NEUTRAL PH

Target

TARGET DNA GYRASE
DNA TOPOISOMERASE 4

DrugCentral

DNA topoisomerase 4 subunit A UNIPROT P72525 parC

Download SDF file

7-[(4E)-3-(aminomethyl)-4-methoxyiminopyrrolidin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

Formula:
C18H20FN5O4

Calculated chemical properties:

MW 388.38
NB_atoms 28
XLogP -0.37
PSA 113.371
NB_HD 2
NB_HA 9
fsp3 0.44
Lipinski(0=no;1=yes) 1

FDA
NDA 021158 (pdf not found) INN (GEMIFLOXACIN MESYLATE) FACTIVE (LG CHEM LTD) APPROVAL= AP YEAR= 2003 NEWMOLECULARENTITY DISCONTINUED
NDA 090466 (pdf not found) INN (GEMIFLOXACIN MESYLATE) GEMIFLOXACIN MESYLATE (ORBION PHARMS) APPROVAL= AP YEAR= 2015 DISCONTINUED