e-Drug3D

823

TIROFIBAN

INN
TIROFIBAN

cas 144494-65-5

CLASS

BLOOD
PLATELET AGGREGATION INHIBITOR
ANTITHROMBOTIC
ANTIANGINAL
FIBRINOLYTIC AGENTS

ROUTE (list)

INJECTION INTRAVENOUS

ATC code

B01AC17

PK parameters

VD 32 LITER
Cl 15.8 LITER / HOUR
PPB 65 PERCENT
t1/2 2 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET PLATELET GLYCOPROTEIN (PG) IIB/IIIA

PDB
2VDM (RE-REFINEMENT OF INTEGRIN ALPHAIIBBETA3 HEADPIECE BOUND TO ANTAGONIST TIROFIBAN)

Ligand code = AGG (link to the list of PDB complexes)

Download experimental 3D coordinates of AGG with added hydrogens

DrugCentral

Integrin alpha-IIb,beta-3 UNIPROT P05106 ITGB3

Download SDF file

(2S)-2-(butylsulfonylamino)-3-[4-(4-piperidin-4-ylbutoxy)phenyl]propanoic acid

Formula:
C22H36N2O5S

Calculated chemical properties:

MW 439.59
NB_atoms 30
XLogP 1.62
PSA 107.031
NB_HD 2
NB_HA 7
fsp3 0.68
Lipinski(0=no;1=yes) 1

FDA
NDA 020912 (label) INN (TIROFIBAN HYDROCHLORIDE) AGGRASTAT (MEDICURE) APPROVAL= AP YEAR= 1998
NDA 020913 (label) INN (TIROFIBAN HYDROCHLORIDE) AGGRASTAT (MEDICURE) APPROVAL= AP YEAR= 1998
NDA 206888 (pdf not found) INN (TIROFIBAN HYDROCHLORIDE) TIROFIBAN HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2021
NDA 216379 (pdf not found) INN (TIROFIBAN HYDROCHLORIDE) TIROFIBAN HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 213947 (pdf not found) INN (TIROFIBAN HYDROCHLORIDE) TIROFIBAN HYDROCHLORIDE (NEXUS) APPROVAL= AP YEAR= 2023