e-Drug3D

820

VALRUBICIN

INN
VALRUBICIN

cas 56124-62-0

CLASS

ANTINEOPLASTIC
BLADDER CANCER
ANTHRACYCLINE
INHIBITS THE INCORPORATION OF NUCLEOSIDES INTO NUCLEIC ACIDS

ROUTE (list)

INTRAVESICAL

ATC code

L01DB09

PK parameters

Solubility

RELATIVELY INSOLUBLE IN WATER

Target

TARGET DNA TOPOISOMERASE II

DrugCentral

DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A

Download SDF file

[2-oxo-2-[(2S,4S)-2,5,12-trihydroxy-4-[5-hydroxy-6-methyl-4-[(2,2,2-trifluoroacetyl)amino]oxan-2-yl]oxy-7-methoxy-6,11-dioxo-3,4-dihydro-1H-tetracen-2-yl]ethyl] pentanoate

Formula:
C34H36F3NO13

Calculated chemical properties:

MW 723.64
NB_atoms 51
XLogP 2.46
PSA 197.639
NB_HD 5
NB_HA 14
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 020892 (label) INN (VALRUBICIN) VALSTAR PRESERVATIVE FREE (ENDO OPERATIONS) APPROVAL= AP YEAR= 1998
NDA 206430 (pdf not found) INN (VALRUBICIN) VALRUBICIN (HIKMA) APPROVAL= AP YEAR= 2019