e-Drug3D

818

cas 74863-84-6

CLASS

BLOOD
ANTITHROMBOTIC
ANTICOAGULANTS
PLATELET AGGREGATION INHIBITORS
THROMBIN INHIBITOR (KI = 0.04 MICROMOLAR)

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 11.3 LITER (65 KILOGRAM)
Cl 20.1 LITER / HOUR (65 KILOGRAM)
PPB 54 PERCENT
t1/2 0.75 HOUR

MW 507.64
NB_atoms 35
XLogP -0.63
PSA 161.165
NB_HD 6
NB_HA 11
fsp3 0.61
Lipinski(0=no;1=yes) 0

FDA
NDA 020883 (label) INN (ARGATROBAN) ARGATROBAN (SANDOZ) APPROVAL= AP YEAR= 2000 NEWMOLECULARENTITY DISCONTINUED
NDA 079238 (pdf not found) INN (ARGATROBAN) ARGATROBAN (PLIVA HRVATSKA DOO) APPROVAL= TA YEAR= 2010
NDA 022359 (pdf not found) INN (ARGATROBAN) ARGATROBAN (BAXTER HLTHCARE CORP) APPROVAL= TA YEAR= 2010
NDA 022485 (label) INN (ARGATROBAN) ARGATROBAN IN SODIUM CHLORIDE (PLANO PHARMS) APPROVAL= AP YEAR= 2011
NDA 201743 (label) INN (ARGATROBAN) ARGATROBAN IN DEXTROSE (SANDOZ) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 022434 (label) INN (ARGATROBAN) ARGATROBAN IN SODIUM CHLORIDE (CIPLA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 203049 (label) INN (ARGATROBAN) ARGATROBAN (HIKMA PHARM CO LTD) APPROVAL= AP YEAR= 2012
NDA 091665 (pdf not found) INN (ARGATROBAN) ARGATROBAN (PH HEALTH) APPROVAL= AP YEAR= 2014
NDA 202626 (pdf not found) INN (ARGATROBAN) ARGATROBAN (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2014
NDA 206769 (label) INN (ARGATROBAN) ARGATROBAN IN 0.9% SODIUM CHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 201811 (label) INN (ARGATROBAN) ARGATROBAN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204120 (pdf not found) INN (ARGATROBAN) ARGATROBAN (HOSPIRA) APPROVAL= AP YEAR= 2016
NDA 205570 (pdf not found) INN (ARGATROBAN) ARGATROBAN IN SODIUM CHLORIDE (GLAND) APPROVAL= AP YEAR= 2017
NDA 206698 (pdf not found) INN (ARGATROBAN) ARGATROBAN (AMNEAL PHARMS CO) APPROVAL= AP YEAR= 2018
NDA 209552 (pdf not found) INN (ARGATROBAN) ARGATROBAN IN SODIUM CHLORIDE (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2018
NDA 212035 (label) INN (ARGATROBAN) ARGATROBAN IN SODIUM CHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2021
NDA 214235 (pdf not found) INN (ARGATROBAN) ARGATROBAN (CAPLIN) APPROVAL= AP YEAR= 2021
NDA 217848 (pdf not found) INN (ARGATROBAN) ARGATROBAN (GLAND) APPROVAL= AP YEAR= 2023