e-Drug3D
816
CILOSTAZOL
INN
CILOSTAZOL
cas 73963-72-1
CLASS
BLOOD
ANTITHROMBOTIC
A QUINOLINONE DERIVATIVE
VASODILATOR AGENTS
PHOSPHODIESTERASE III INHIBITORS
ROUTE (list)
ORAL
ATC code
B01AC23
PK parameters
Tmax 2 HOUR
PPB 96.5 PERCENT
t1/2 12 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET PHOSPHODIESTERASE III (PDE)
cGMP-inhibited 3,5-cyclic phosphodiesterase A UNIPROT Q14432 PDE3A
Formula:
C20H27N5O2
Calculated chemical properties:
MW 369.47
NB_atoms 27
XLogP 3.46
PSA 83.103
NB_HD 1
NB_HA 7
fsp3 0.60
Lipinski(0=no;1=yes) 1
NB_atoms 27
XLogP 3.46
PSA 83.103
NB_HD 1
NB_HA 7
fsp3 0.60
Lipinski(0=no;1=yes) 1
FDA
NDA 020863 (label) INN (CILOSTAZOL) PLETAL (OTSUKA) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY DISCONTINUED
NDA 077019 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077021 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077022 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2004
NDA 077027 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (TEVA) APPROVAL= AP YEAR= 2004
NDA 077028 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2004
NDA 077030 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (APOTEX) APPROVAL= AP YEAR= 2004
NDA 077020 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077024 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (HIKMA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077150 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2005 DISCONTINUED OBSOLETE
NDA 077310 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077208 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2006
NDA 077323 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (RISING) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077898 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (PLIVA HRVATSKA DOO) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077708 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (SANKALP LIFECARE) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077722 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 077831 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 020863 (label) INN (CILOSTAZOL) PLETAL (OTSUKA) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY DISCONTINUED
NDA 077019 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (AUROBINDO PHARMA USA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077021 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 077022 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2004
NDA 077027 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (TEVA) APPROVAL= AP YEAR= 2004
NDA 077028 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2004
NDA 077030 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (APOTEX) APPROVAL= AP YEAR= 2004
NDA 077020 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077024 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (HIKMA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077150 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2005 DISCONTINUED OBSOLETE
NDA 077310 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077208 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2006
NDA 077323 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (RISING) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077898 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (PLIVA HRVATSKA DOO) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077708 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (SANKALP LIFECARE) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077722 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 077831 (pdf not found) INN (CILOSTAZOL) CILOSTAZOL (CHARTWELL RX) APPROVAL= AP YEAR= 2012