e-Drug3D

812

cas 105462-24-6

CLASS

MUSCULO-SKELETAL
OSTEOPOROSIS
OSTEOCLASTIC RESORPTION INHIBITOR
BISPHOSPHONATES
HAS AN AFFINITY FOR HYDROXYAPATITE CRYSTALS IN BONE AND ACTS AS AN ANTIRESORPTIVE AGENT

ROUTE (list)

ORAL

PK parameters

F 0.63 PERCENT
Tmax 1 HOUR
VD 897 LITER (65 KILOGRAM)
Cl 7.3 LITER / HOUR
PPB 24 PERCENT
t1/2 561 HOUR

TARGET FARNESYL PYROPHOSPHATE SYNTHASE

PDB
4KPD (CRYSTAL STRUCTURE OF HUMAN FARNESYL PYROPHOSPHATE SYNTHASE (Y204F) MUTANT COMPLEXED WITH MG, RISEDRONATE AND ISOPENTENYL PYROPHOSPHATE)

Ligand code = RIS (link to the list of PDB complexes)

Download experimental 3D coordinates of RIS with added hydrogens

MW 279.08
NB_atoms 17
XLogP -2.90
PSA 140.254
NB_HD 1
NB_HA 8
fsp3 0.29
Lipinski(0=no;1=yes) 0

FDA
NDA 020835 (label) INN (RISEDRONATE SODIUM) ACTONEL (APIL) APPROVAL= AP YEAR= 1998
NDA 021823 (label) INN (CALCIUM CARBONATE ; RISEDRONATE SODIUM) ACTONEL WITH CALCIUM COPACKAGED (WARNER CHILCOTT) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077132 (label) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2007
NDA 022560 (label) INN (RISEDRONATE SODIUM) ATELVIA (APIL) APPROVAL= AP YEAR= 2010
NDA 079215 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014
NDA 200477 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 090877 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (APOTEX) APPROVAL= AP YEAR= 2014
NDA 090886 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2014
NDA 200296 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2015
NDA 203217 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2015
NDA 203533 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 206768 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016
NDA 203822 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 205066 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (IMPAX LABS INC) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 205280 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (ORBION PHARMS) APPROVAL= AP YEAR= 2019
NDA 207516 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (HANGZHOU BINJIANG) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 203925 (pdf not found) INN (RISEDRONATE SODIUM) RISEDRONATE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2019 DISCONTINUED