e-Drug3D

809

cas 158966-92-8

CLASS

RESPIRATORY SYSTEM
LEUKOTRIENE RECEPTOR ANTAGONIST
ANTIASTHMATIC
CHRONIC TREATMENT OF ASTHMA

ROUTE (list)

ORAL

PK parameters

F 64 PERCENT
Tmax 3.5 HOUR
VD 9.5 LITER
Cl 2.7 LITER / HOUR
PPB 99 PERCENT
t1/2 4.1 HOUR

TARGET CYSTEINYL LEUKOTRIENE RECEPTOR 1 (CYSLT1)

PDB
2NNI (CYP2C8DH COMPLEXED WITH MONTELUKAST)

Ligand code = MTK (link to the list of PDB complexes)

Download experimental 3D coordinates of MTK with added hydrogens

MW 585.16
NB_atoms 41
XLogP 7.61
PSA 54.828
NB_HD 1
NB_HA 4
fsp3 0.31
Lipinski(0=no;1=yes) 0

FDA
NDA 020829 (pdf not found) INN (MONTELUKAST SODIUM) SINGULAIR (ORGANON) APPROVAL= AP YEAR= 1998
NDA 020830 (pdf not found) INN (MONTELUKAST SODIUM) SINGULAIR (ORGANON) APPROVAL= AP YEAR= 1998
NDA 021409 (pdf not found) INN (MONTELUKAST SODIUM) SINGULAIR (ORGANON) APPROVAL= AP YEAR= 2002
NDA 078605 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (TEVA PHARMS) APPROVAL= AP YEAR= 2012
NDA 078723 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (TEVA PHARMS) APPROVAL= AP YEAR= 2012
NDA 079103 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 079142 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (NATCO PHARMA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090655 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (HIKMA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091128 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (HIKMA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090984 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 090926 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 091414 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (SANDOZ INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091576 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (STRIDES PHARMA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091588 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (NEW HEIGHTSRX) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 090955 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (TEVA PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 200405 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (LANNETT CO INC) APPROVAL= AP YEAR= 2012
NDA 200889 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (SANDOZ INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201294 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (APOTEX CORP) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201508 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201515 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (TORRENT PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 201522 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2012
NDA 201581 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (SENORES PHARMS) APPROVAL= AP YEAR= 2012
NDA 201582 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 202096 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 202468 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 202717 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2012
NDA 202776 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202906 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 202843 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (HETERO LABS LTD V) APPROVAL= AP YEAR= 2014
NDA 202859 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (UNIMARK REMEDIES LTD) APPROVAL= AP YEAR= 2014
NDA 203037 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (UNIMARK REMEDIES LTD) APPROVAL= AP YEAR= 2014
NDA 203366 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203328 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203432 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203438 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2015
NDA 203582 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2015
NDA 203795 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (JUBILANT GENERICS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204093 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (HETERO LABS LTD V) APPROVAL= AP YEAR= 2015
NDA 204290 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (UNICHEM) APPROVAL= AP YEAR= 2015
NDA 204604 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2015
NDA 205695 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (ANBISON LAB) APPROVAL= AP YEAR= 2015
NDA 205683 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (ANBISON LAB) APPROVAL= AP YEAR= 2016
NDA 207463 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (CIPLA) APPROVAL= AP YEAR= 2016
NDA 206112 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (L PERRIGO CO) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 209011 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (RISING) APPROVAL= AP YEAR= 2017
NDA 209012 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (RISING) APPROVAL= AP YEAR= 2017
NDA 207464 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2018
NDA 208621 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (UNICHEM) APPROVAL= AP YEAR= 2018
NDA 210431 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (TORRENT) APPROVAL= AP YEAR= 2018
NDA 213471 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2020
NDA 205107 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2020
NDA 205319 (pdf not found) INN (MONTELUKAST SODIUM) MONTELUKAST SODIUM (BRECKENRIDGE) APPROVAL= AP YEAR= 2020 DISCONTINUED