e-Drug3D

805

BRINZOLAMIDE

INN
BRINZOLAMIDE

cas 138890-62-7

CLASS

SENSORY
ANTIGLAUCOMA
CARBONIC ANHYDRASE INHIBITORS
OPHTHALMICS

ROUTE (list)

OPHTHALMIC

ATC code

S01EC04
S01EC54

PK parameters

Tmax 1 HOUR
PPB 60 PERCENT
t1/2 2664 HOUR

Solubility

INSOLUBLE IN WATER

Target

TARGET CARBONIC ANHYDRASE II

PDB
4M2V (GENETICALLY ENGINEERED CARBONIC ANHYDRASE IX IN COMPLEX WITH BRINZOLAMIDE)

Ligand code = BZ1 (link to the list of PDB complexes)

Download experimental 3D coordinates of BZ1 with added hydrogens

DrugCentral

Carbonic anhydrase 2 UNIPROT P00918 CA2

Download SDF file

(4R)-4-ethylamino-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[4,5-e]thiazine-6-sulfonamide

Formula:
C12H21N3O5S3

Calculated chemical properties:

MW 383.53
NB_atoms 23
XLogP 0.09
PSA 122.617
NB_HD 3
NB_HA 8
fsp3 0.67
Lipinski(0=no;1=yes) 1

FDA
NDA 020816 (pdf not found) INN (BRINZOLAMIDE) AZOPT (SANDOZ) APPROVAL= AP YEAR= 1998
NDA 204251 (pdf not found) INN (BRIMONIDINE TARTRATE ; BRINZOLAMIDE) SIMBRINZA (ALCON LABS INC) APPROVAL= AP YEAR= 2013
NDA 209406 (pdf not found) INN (BRINZOLAMIDE) BRINZOLAMIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2020
NDA 204884 (pdf not found) INN (BRINZOLAMIDE) BRINZOLAMIDE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2021
NDA 211914 (pdf not found) INN (BRINZOLAMIDE) BRINZOLAMIDE (PADAGIS US) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 212137 (pdf not found) INN (BRINZOLAMIDE ; BRIMONIDINE TARTRATE) BRINZOLAMIDE; BRIMONIDINE TARTRATE (PERRIGO PHARMA INTERNATIONAL DAC) APPROVAL= TA YEAR= 2023