e-Drug3D

804

cas 84449-90-1

CLASS

GENITO
TREATMENT AND PREVENTION OF OSTEOPOROSIS IN POSTMENOPAUSAL WOMEN
ANTINEOPLASTIC
ANTIHYPOCALCEMIC AGENTS
BONE DENSITY CONSERVATION AGENTS
ESTROGEN RECEPTOR AGONIST/ANTAGONIST

ROUTE (list)

ORAL

PK parameters

F 2 PERCENT
VD 152620 LITER (65 KILOGRAM)
Cl 2866 LITER / HOUR (65 KILOGRAM)
PPB 95 PERCENT
t1/2 27.7 HOUR

TARGET ESTROGEN RECEPTOR BETA

PDB
1ERR (HUMAN ESTROGEN RECEPTOR LIGAND-BINDING DOMAIN IN COMPLEX WITH RALOXIFENE)

Ligand code = RAL (link to the list of PDB complexes)

Download experimental 3D coordinates of RAL with added hydrogens

MW 473.58
NB_atoms 34
XLogP 6.08
PSA 75.243
NB_HD 2
NB_HA 5
fsp3 0.25
Lipinski(0=no;1=yes) 0

FDA
NDA 020815 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) EVISTA (LILLY) APPROVAL= AP YEAR= 1997
NDA 022042 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) EVISTA (LILLY) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 078193 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014
NDA 090842 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (INVAGEN PHARMS) APPROVAL= AP YEAR= 2014
NDA 200825 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 2015
NDA 204310 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2015
NDA 204491 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2016
NDA 208206 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 206384 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2016
NDA 211324 (pdf not found) INN (RALOXIFENE HYDROCHLORIDE) RALOXIFENE HYDROCHLORIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2020