e-Drug3D

798

ORLISTAT

INN
ORLISTAT

cas 96829-58-2

CLASS

METABOLISM
ANTIOBESITY
HYPOLIPIDEMIC
COVALENT INHIBITOR OF GASTROINTESTINAL LIPASES
TREATMENT OF OBESITY

ROUTE (list)

ORAL

ATC code

A08AB01

PK parameters

Tmax 8 HOUR
PPB 99 PERCENT
t1/2 1.5 HOUR

Solubility

INSOLUBLE IN WATER

Target

TARGET GASTRIC LIPASE
PANCREATIC LIPASE

DrugCentral

Pancreatic triacylglycerol lipase UNIPROT P16233 PNLIP

Gastric triacylglycerol lipase UNIPROT P07098 LIPF

Download SDF file

[(2S)-1-[(2S,3S)-3-hexyl-4-oxooxetan-2-yl]tridecan-2-yl] (2S)-2-formamido-4-methylpentanoate

Formula:
C29H53NO5

Calculated chemical properties:

MW 495.72
NB_atoms 35
XLogP 6.88
PSA 73.826
NB_HD 1
NB_HA 6
fsp3 0.90
Lipinski(0=no;1=yes) 0

FDA
NDA 020766 (pdf not found) INN (ORLISTAT) XENICAL (CHEPLAPHARM) APPROVAL= AP YEAR= 1999
NDA 021887 (pdf not found) INN (ORLISTAT) ALLI (HALEON US HOLDINGS) APPROVAL= AP YEAR= 2007