e-Drug3D

793

CERIVASTATIN

DISCONTINUED

INN
CERIVASTATIN

cas 145599-86-6

CLASS

CARDIOVASCULAR
HYPOCHOLESTEROLEMIC
3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE (HMG-COA) INHIBITOR
ANTI-LIPIDEMIC AGENTS

ROUTE (list)

ORAL

ATC code

C10AA06

PK parameters

F 60 PERCENT
Tmax 2 HOUR
VD 19.5 LITER (65 KILOGRAM)
Cl 12.5 LITER / HOUR
PPB 99 PERCENT
t1/2 3 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE

3-hydroxy-3-methylglutaryl-coenzyme A reductase UNIPROT P04035 HMGCR

Download SDF file

(E,3R,5S)-7-[4-(4-fluorophenyl)-5-(methoxymethyl)-2,6-di(propan-2-yl)pyridin-3-yl]-3,5-dihydroxyhept-6-enoic acid

Formula:
C26H34FNO5

Calculated chemical properties:

MW 458.53
NB_atoms 33
XLogP 3.55
PSA 92.215
NB_HD 2
NB_HA 6
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 020740 (label) INN (CERIVASTATIN SODIUM) BAYCOL (BAYER PHARMS) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED