e-Drug3D

792

cas 112809-51-5

CLASS

ANTINEOPLASTIC
AROMATASE INHIBITORS
TREATMENT OF POSTMENOPAUSAL WOMEN WITH EARLY BREAST CANCER (INHIBITOR OF ESTROGEN SYNTHESIS)

ROUTE (list)

ORAL

PK parameters

VD 123.5 LITER (65 KILOGRAM)
Cl 2.22 LITER / HOUR (65 KILOGRAM)
PPB 39 PERCENT
t1/2 48 HOUR

MW 285.31
NB_atoms 22
XLogP 2.66
PSA 63.967
NB_HD 0
NB_HA 5
fsp3 0.06
Lipinski(0=no;1=yes) 1

FDA
NDA 020726 (pdf not found) INN (LETROZOLE) FEMARA (NOVARTIS PHARMS) APPROVAL= AP YEAR= 1997
NDA 078190 (pdf not found) INN (LETROZOLE) LETROZOLE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090405 (pdf not found) INN (LETROZOLE) LETROZOLE (ZYDUS PHARMS USA INC) APPROVAL= TA YEAR= 2010
NDA 090196 (pdf not found) INN (LETROZOLE) LETROZOLE (SYNTHON PHARMS) APPROVAL= TA YEAR= 2010
NDA 090289 (pdf not found) INN (LETROZOLE) LETROZOLE (TEVA PHARMS) APPROVAL= AP YEAR= 2011
NDA 090838 (pdf not found) INN (LETROZOLE) LETROZOLE (HIKMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090491 (pdf not found) INN (LETROZOLE) LETROZOLE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090934 (pdf not found) INN (LETROZOLE) LETROZOLE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2011
NDA 090789 (pdf not found) INN (LETROZOLE) LETROZOLE (STRIDES PHARMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091098 (pdf not found) INN (LETROZOLE) LETROZOLE (LANNETT CO INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091191 (pdf not found) INN (LETROZOLE) LETROZOLE (RYAN LABS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091466 (pdf not found) INN (LETROZOLE) LETROZOLE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091638 (pdf not found) INN (LETROZOLE) LETROZOLE (IMPAX LABS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200161 (pdf not found) INN (LETROZOLE) LETROZOLE (NATCO PHARMA LTD) APPROVAL= AP YEAR= 2011
NDA 201804 (pdf not found) INN (LETROZOLE) LETROZOLE (INDICUS PHARMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090292 (pdf not found) INN (LETROZOLE) LETROZOLE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091303 (pdf not found) INN (LETROZOLE) LETROZOLE (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202716 (pdf not found) INN (LETROZOLE) LETROZOLE (CHARTWELL RX) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202048 (pdf not found) INN (LETROZOLE) LETROZOLE (LANNETT CO INC) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 203796 (pdf not found) INN (LETROZOLE) LETROZOLE (HIKMA PHARMS) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 209935 (pdf not found) INN (LETROZOLE ; RIBOCICLIB SUCCINATE) KISQALI FEMARA CO-PACK COPACKAGED (NOVARTIS) APPROVAL= AP YEAR= 2017
NDA 205869 (pdf not found) INN (LETROZOLE) LETROZOLE (BEIJING YILING) APPROVAL= AP YEAR= 2018
NDA 211717 (pdf not found) INN (LETROZOLE) LETROZOLE (EUGIA PHARMA) APPROVAL= AP YEAR= 2019
NDA 215975 (pdf not found) INN (LETROZOLE ; RIBOCICLIB SUCCINATE) LETROZOLE;VRIBOCICLIB SUCCINATE (MSN LABS PVT LTD) APPROVAL= TA YEAR= 2023