e-Drug3D

791

cas 99011-02-6

CLASS

DERMATOLOGICALS
IMMUNOMODULATOR
ANTIVIRAL
ADJUVANTS, IMMUNOLOGIC
ANTINEOPLASTIC AGENTS
INTERFERON INDUCERS
TREATMENT OF ACTINIC KERATOSIS, UPERFICIAL BASAL CELL CARCINOMA AND EXTERNAL GENITAL WARTS
TOLL-LIKE RECEPTOR 7 AGONIST THAT ACTIVATES IMMUNE CELLS

ROUTE (list)

TOPICAL

PK parameters

Tmax 9 HOUR
t1/2 29.3 HOUR

TARGET TOLL-LIKE RECEPTOR 7

PDB
5LBT (STRUCTURE OF THE HUMAN QUINONE REDUCTASE 2 (NQO2) IN COMPLEX WITH IMIQUIMOD)

Ligand code = 6T0 (link to the list of PDB complexes)

Download experimental 3D coordinates of 6T0 with added hydrogens

MW 240.31
NB_atoms 18
XLogP 2.82
PSA 48.512
NB_HD 2
NB_HA 4
fsp3 0.29
Lipinski(0=no;1=yes) 1

FDA
NDA 020723 (label) INN (IMIQUIMOD) ALDARA (BAUSCH) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 022483 (label) INN (IMIQUIMOD) ZYCLARA (BAUSCH) APPROVAL= AP YEAR= 2010
NDA 078548 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (FOUGERA PHARMS) APPROVAL= AP YEAR= 2010
NDA 078837 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2010
NDA 091044 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (ENCUBE) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200173 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (TARO) APPROVAL= AP YEAR= 2011
NDA 200481 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (COSETTE) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 201153 (label) INN (IMIQUIMOD) ZYCLARA (GRACEWAY) APPROVAL= AP YEAR= 2011 NEWAPPLICATION
NDA 091308 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201994 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (GLENMARK PHARMS INC) APPROVAL= AP YEAR= 2012
NDA 202002 (label) INN (IMIQUIMOD) IMIQUIMOD (STRIDES PHARMA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 205971 (pdf not found) INN (IMIQUIMOD) IMIQUIMOD (TARO) APPROVAL= AP YEAR= 2021