e-Drug3D

787

cas 134523-00-5

CLASS

CARDIOVASCULAR
ANTIHYPERLIPIDEMIC
HMG-COA REDUCTASE INHIBITOR
ANTICHOLESTEREMIC AGENTS

ROUTE (list)

ORAL

PK parameters

F 14 PERCENT
Tmax 1.5 HOUR
VD 381 LITER
Cl 18.8 LITER / HOUR (EQN)
PPB 98 PERCENT
t1/2 14 HOUR

TARGET 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE

PDB
1HWK (COMPLEX OF THE CATALYTIC PORTION OF HUMAN HMG-COA REDUCTASE WITH ATORVASTATIN)

Ligand code = 117 (link to the list of PDB complexes)

Download experimental 3D coordinates of 117 with added hydrogens

MW 557.62
NB_atoms 41
XLogP 4.98
PSA 101.97
NB_HD 3
NB_HA 7
fsp3 0.27
Lipinski(0=no;1=yes) 0

FDA
NDA 020702 (label) INN (ATORVASTATIN CALCIUM) LIPITOR (UPJOHN) APPROVAL= AP YEAR= 1996
NDA 021540 (label) INN (AMLODIPINE BESYLATE ; ATORVASTATIN CALCIUM) CADUET (PHARMACIA) APPROVAL= AP YEAR= 2004
NDA 076477 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078773 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (TEVA PHARMS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091226 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2012
NDA 077575 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 090548 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (APOTEX INC) APPROVAL= AP YEAR= 2012
NDA 091650 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 202357 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2012
NDA 091624 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (LANNETT CO INC) APPROVAL= AP YEAR= 2013
NDA 200153 (label) INN (ATORVASTATIN CALCIUM ; EZETIMIBE) LIPTRUZET (ORGANON) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 200465 (pdf not found) INN (AMLODIPINE BESYLATE ; ATORVASTATIN CALCIUM) AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM (MYLAN) APPROVAL= AP YEAR= 2013
NDA 203874 (pdf not found) INN (AMLODIPINE BESYLATE ; ATORVASTATIN CALCIUM) AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM (DR REDDYS) APPROVAL= AP YEAR= 2014
NDA 205519 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2016
NDA 204846 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (INVAGEN PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 205300 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2017
NDA 206084 (pdf not found) INN (ATORVASTATIN CALCIUM ; EZETIMIBE) LYPQOZET (ALTHERA PHARMS) APPROVAL= AP YEAR= 2017
NDA 207687 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2018
NDA 206536 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 209288 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2018
NDA 209912 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (GRAVITI PHARMS) APPROVAL= AP YEAR= 2018
NDA 204991 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (LUPIN LTD) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 207762 (pdf not found) INN (AMLODIPINE BESYLATE ; ATORVASTATIN CALCIUM) AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2019
NDA 211933 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (MSN) APPROVAL= AP YEAR= 2019
NDA 205199 (pdf not found) INN (AMLODIPINE BESYLATE ; ATORVASTATIN CALCIUM) AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM (APOTEX) APPROVAL= AP YEAR= 2019
NDA 205945 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (MICRO LABS LTD INDIA) APPROVAL= AP YEAR= 2019
NDA 208478 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (PERRIGO R AND D) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 213853 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (UMEDICA) APPROVAL= AP YEAR= 2020
NDA 214659 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (DR REDDYS) APPROVAL= AP YEAR= 2021
NDA 214969 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (APOTEX) APPROVAL= AP YEAR= 2021
NDA 216436 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (BIOCON PHARMA) APPROVAL= AP YEAR= 2022
NDA 216848 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (LEPU PHARM) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 213260 (label) INN (ATORVASTATIN CALCIUM) ATORVALIQ (CMP DEV LLC) APPROVAL= AP YEAR= 2023
NDA 212103 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 214344 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (HETERO LABS LTD V) APPROVAL= AP YEAR= 2023
NDA 217634 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (STRIDES PHARMA) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 208480 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 211886 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (SHANDONG XINHUA) APPROVAL= AP YEAR= 2024
NDA 214513 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (LAURUS) APPROVAL= AP YEAR= 2024
NDA 217081 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (MANKIND PHARMA) APPROVAL= AP YEAR= 2024
NDA 217118 (pdf not found) INN (ATORVASTATIN CALCIUM) ATORVASTATIN CALCIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 217279 (pdf not found) INN (AMLODIPINE BESYLATE ; ATORVASTATIN CALCIUM) AMLODIPINE BESYLATE AND ATORVASTATIN CALCIUM (ALEMBIC) APPROVAL= AP YEAR= 2025