e-Drug3D
785
FOMEPIZOLE
INN
FOMEPIZOLE
cas 7554-65-6
CLASS
VARIOUS
ANTIDOTE
OMPETITIVE INHIBITOR OF ALCOHOL DEHYDROGENASE
ROUTE (list)
INJECTION
ATC code
V03AB34
PK parameters
VD 52.6 LITER (65 KILOGRAM)
Solubility
SOLUBLE IN WATER
TARGET ALCOHOL DEHYDROGENASE
PDB
3E4E (HUMAN CYTOCHROME P450 2E1 IN COMPLEX WITH THE INHIBITOR 4-METHYLPYRAZOLE)
Ligand code = 4PZ (link to the list of PDB complexes)
Download experimental 3D coordinates of 4PZ with added hydrogens
Alcohol dehydrogenase UNIPROT P00325 ADH1B
Formula:
C4H6N2
Calculated chemical properties:
MW 82.11
NB_atoms 6
XLogP 0.72
PSA 27.487
NB_HD 1
NB_HA 2
fsp3 0.25
Lipinski(0=no;1=yes) 1
NB_atoms 6
XLogP 0.72
PSA 27.487
NB_HD 1
NB_HA 2
fsp3 0.25
Lipinski(0=no;1=yes) 1
FDA
NDA 020696 (pdf not found) INN (FOMEPIZOLE) ANTIZOL (PAR PHARM INC) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED
NDA 078368 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (AM REGENT) APPROVAL= AP YEAR= 2007
NDA 078537 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (NAVINTA LLC) APPROVAL= AP YEAR= 2008
NDA 078639 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2008
NDA 079033 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 216791 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (GLAND) APPROVAL= AP YEAR= 2023
NDA 020696 (pdf not found) INN (FOMEPIZOLE) ANTIZOL (PAR PHARM INC) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED
NDA 078368 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (AM REGENT) APPROVAL= AP YEAR= 2007
NDA 078537 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (NAVINTA LLC) APPROVAL= AP YEAR= 2008
NDA 078639 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2008
NDA 079033 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 216791 (pdf not found) INN (FOMEPIZOLE) FOMEPIZOLE (GLAND) APPROVAL= AP YEAR= 2023