e-Drug3D

784

GREPAFLOXACIN

DISCONTINUED

INN
GREPAFLOXACIN

cas 119914-60-2

CLASS

ANTIBIOTIC
ANTIBACTERIAL
ANTIINFECTIVES
INHIBITOR

ROUTE (list)

ORAL

ATC code

J01MA11

PK parameters

F 70 PERCENT
VD 325 LITER (65 KILOGRAM)
Cl 15 LITER / HOUR (EQN)
PPB 50 PERCENT
t1/2 15 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET DNA TOPOISOMERASE II (DNA GYRASE)
DNA TOPOISOMERASE IV

DNA topoisomerase 4 UNIPROT P72525 parC

DNA gyrase UNIPROT P0A4L9 gyrB

Download SDF file

1-cyclopropyl-6-fluoro-5-methyl-7-(3-methylpiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid

Formula:
C19H22FN3O3

Calculated chemical properties:

MW 358.39
NB_atoms 26
XLogP 0.95
PSA 70.146
NB_HD 1
NB_HA 6
fsp3 0.47
Lipinski(0=no;1=yes) 1

FDA
NDA 020695 (pdf not found) INN (GREPAFLOXACIN HYDROCHLORIDE) RAXAR (OTSUKA) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED