e-Drug3D

783

cas 120014-06-4

CLASS

NERVOUS SYSTEM
ACETYLCHOLINESTERASE INHIBITOR (REVERSIBLE)
COGNITIVE ENHANCER
ANTI-ALZHEIMER'S DISEASE
CHOLINESTERASE INHIBITORS
INCREASES CONCENTRATION OF ACETYLCHOLINE

ROUTE (list)

ORAL TRANSDERMAL

PK parameters

Tmax 3 HOUR
VD 910 LITER (65 KILOGRAM)
Cl 8.4 LITER / HOUR (65 KILOGRAM)
PPB 96 PERCENT
t1/2 70 HOUR

MW 379.48
NB_atoms 28
XLogP 4.36
PSA 43.521
NB_HD 0
NB_HA 4
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 020690 (label) INN (DONEPEZIL HYDROCHLORIDE) ARICEPT (EISAI INC) APPROVAL= AP YEAR= 1996
NDA 021719 (label) INN (DONEPEZIL HYDROCHLORIDE) ARICEPT (EISAI INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021720 (label) INN (DONEPEZIL HYDROCHLORIDE) ARICEPT ODT (EISAI INC) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076893 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (PAR PHARM) APPROVAL= TA YEAR= 2007
NDA 077975 (label) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 076786 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 077344 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078388 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022568 (label) INN (DONEPEZIL HYDROCHLORIDE) ARICEPT (EISAI INC) APPROVAL= AP YEAR= 2010
NDA 078662 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (STRIDES PHARMA) APPROVAL= AP YEAR= 2011
NDA 078841 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (APOTEX) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090056 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (AUROBINDO) APPROVAL= AP YEAR= 2011
NDA 090686 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (TORRENT PHARMS) APPROVAL= AP YEAR= 2011
NDA 090175 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090247 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (HIKMA PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090290 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090425 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2011
NDA 090493 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SUN PHARM INDS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 077518 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (CIPLA LTD) APPROVAL= AP YEAR= 2011
NDA 090521 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (NATCO PHARMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090551 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ESJAY PHARMA) APPROVAL= AP YEAR= 2011
NDA 090768 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2011
NDA 091198 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091267 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (WOCKHARDT) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200292 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (PRINSTON INC) APPROVAL= AP YEAR= 2011
NDA 201001 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 201335 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 201634 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (INDICUS PHARMA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090100 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2012
NDA 201146 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 201787 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 201724 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ALEMBIC PHARMS LTD) APPROVAL= AP YEAR= 2013
NDA 202114 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2013
NDA 202542 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202723 (label) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 2013
NDA 202631 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2014
NDA 203104 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (TWI PHARMS) APPROVAL= AP YEAR= 2014
NDA 203907 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2014
NDA 206439 (label) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) NAMZARIC (ABBVIE) APPROVAL= AP YEAR= 2014
NDA 203034 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (HETERO LABS LTD V) APPROVAL= AP YEAR= 2015
NDA 204293 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (SUN PHARM) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202415 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202656 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 202782 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (LUPIN LTD) APPROVAL= AP YEAR= 2015
NDA 203114 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (OSMOTICA PHARM US) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203419 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203656 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 203713 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (DEXCEL) APPROVAL= AP YEAR= 2016
NDA 204831 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (UNICHEM) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 202410 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (HISUN PHARM HANGZHOU) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 208328 (label) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE (AMNEAL) APPROVAL= AP YEAR= 2017
NDA 203162 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 204609 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (CADILA PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 205269 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE) DONEPEZIL HYDROCHLORIDE (HISUN PHARM HANGZHOU) APPROVAL= AP YEAR= 2018
NDA 212304 (label) INN (DONEPEZIL HYDROCHLORIDE) ADLARITY (CORIUM) APPROVAL= AP YEAR= 2022
NDA 208237 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE (ANI PHARMS) APPROVAL= AP YEAR= 2023
NDA 208672 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2025
NDA 216901 (pdf not found) INN (DONEPEZIL HYDROCHLORIDE ; MEMANTINE HYDROCHLORIDE) MEMANTINE HYDROCHLORIDE AND DONEPEZIL HYDROCHLORIDE (XIAMEN LP PHARM CO) APPROVAL= AP YEAR= 2025