e-Drug3D

781

MIFEPRISTONE

INN
MIFEPRISTONE

cas 84371-65-3

CLASS

GENITO
CONTRACEPTIVE
ANTIPROGESTERONE
USED TO END AN EARLY PREGNANCY

ROUTE (list)

ORAL

ATC code

G03XB01
G03XB51

PK parameters

F 69 PERCENT
Tmax 1.5 HOUR
PPB 98 PERCENT
t1/2 18 HOUR

Solubility

POORLY SOLUBLE IN WATER

Target

TARGET PROGESTERONE RECEPTOR

PDB
3H52 (CRYSTAL STRUCTURE OF THE ANTAGONIST FORM OF HUMAN GLUCOCORTICOID RECEPTOR)

Ligand code = 486 (link to the list of PDB complexes)

Download experimental 3D coordinates of 486 with added hydrogens

DrugCentral

Glucocorticoid receptor UNIPROT P04150 NR3C1

Progesterone receptor UNIPROT P06401 PGR

Download SDF file

(8S,11R,13S,14S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one

Formula:
C29H35NO2

Calculated chemical properties:

MW 429.58
NB_atoms 32
XLogP 5.41
PSA 40.9
NB_HD 1
NB_HA 3
fsp3 0.55
Lipinski(0=no;1=yes) 0

FDA
NDA 020687 (pdf not found) INN (MIFEPRISTONE) MIFEPREX (DANCO LABS LLC) APPROVAL= AP YEAR= 2000
NDA 202107 (pdf not found) INN (MIFEPRISTONE) KORLYM (CORCEPT THERAP) APPROVAL= AP YEAR= 2012
NDA 091178 (pdf not found) INN (MIFEPRISTONE) MIFEPRISTONE (GENBIOPRO) APPROVAL= AP YEAR= 2019
NDA 211436 (pdf not found) INN (MIFEPRISTONE) MIFEPRISTONE (TEVA PHARMS USA INC) APPROVAL= AP YEAR= 2020