e-Drug3D

780

MIGLITOL

INN
MIGLITOL

cas 72432-03-2

CLASS

METABOLISM
ANTIDIABETIC
HYPOGLYCEMIC AGENTS
MEMBRANE-BOUND INTESTINAL ALPHA-GLUCOSIDE HYDROLASE INHIBITOR
MANAGEMENT OF ON-INSULIN-DEPENDENT DIABETES MELLITUS (NIDDM)

ROUTE (list)

ORAL

ATC code

A10BF02

PK parameters

Tmax 2.5 HOUR
VD 11.7 LITER (65 KILOGRAM)
Cl 6.6 LITER / HOUR (65 KILOGRAM)
PPB 4 PERCENT
t1/2 2 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET ALPHA-GLUCOSIDASE

PDB
5NN6 (CRYSTAL STRUCTURE OF HUMAN LYSOSOMAL ACID-ALPHA-GLUCOSIDASE, GAA, IN COMPLEX WITH N-HYDROXYETHYL-1-DEOXYNOJIRIMYCIN)

Ligand code = MIG (link to the list of PDB complexes)

Download experimental 3D coordinates of MIG with added hydrogens

DrugCentral

Maltase-glucoamylase, intestinal UNIPROT O43451 MGAM

Lysosomal alpha-glucosidase UNIPROT P10253 GAA

Download SDF file

(2R,3R,4R,5S)-1-(2-hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

Formula:
C8H17NO5

Calculated chemical properties:

MW 207.23
NB_atoms 14
XLogP -3.26
PSA 103.373
NB_HD 5
NB_HA 6
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 020682 (label) INN (MIGLITOL) GLYSET (PFIZER) APPROVAL= AP YEAR= 1996
NDA 203965 (pdf not found) INN (MIGLITOL) MIGLITOL (WESTMINSTER PHARMS) APPROVAL= AP YEAR= 2015