e-Drug3D

778

cas 123948-87-8

CLASS

ANTINEOPLASTIC
TOPOISOMERASE INHIBITOR
TREATMENT OF METASTATIC CARCINOMA OF THE OVARY, SMALL CELL LUNG CANCER
DERIVATIVE OF CAMPTOTHECIN

ROUTE (list)

INJECTION ORAL INTRAVENOUS

PK parameters

F 40 PERCENT
Tmax 1.5 HOUR
VD 117 LITER (65 KILOGRAM)
Cl 50.7 LITER / HOUR
PPB 35 PERCENT
t1/2 2.5 HOUR

TARGET TOPOISOMERASE I

PDB
1RRJ (STRUCTURAL MECHANISMS OF CAMPTOTHECIN RESISTANCE BY MUTATIONS IN HUMAN TOPOISOMERASE I)

Ligand code = TTC (link to the list of PDB complexes)

Download experimental 3D coordinates of TTC with added hydrogens

MW 421.44
NB_atoms 31
XLogP 1.85
PSA 103.012
NB_HD 2
NB_HA 8
fsp3 0.35
Lipinski(0=no;1=yes) 1

FDA
NDA 020671 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) HYCAMTIN (SANDOZ) APPROVAL= AP YEAR= 1996
NDA 020981 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) HYCAMTIN (SANDOZ) APPROVAL= AP YEAR= 2007
NDA 091089 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010
NDA 091376 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090620 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2010
NDA 091199 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (TEYRO LABS) APPROVAL= AP YEAR= 2010
NDA 091284 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (SAGENT PHARMS) APPROVAL= AP YEAR= 2011
NDA 200199 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN (SANDOZ INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 200582 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (HOSPIRA INC) APPROVAL= AP YEAR= 2011
NDA 201191 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2011
NDA 022453 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 091542 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201166 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202203 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202351 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 206962 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (NOVAST LABS) APPROVAL= AP YEAR= 2016
NDA 204406 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 206074 (pdf not found) INN (TOPOTECAN HYDROCHLORIDE) TOPOTECAN HYDROCHLORIDE (DASH PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED