e-Drug3D

771

CIDOFOVIR

INN
CIDOFOVIR

(is an active metabolite) (has an active metabolite)

cas 113852-37-2

CLASS

ANTIINFECTIVES
ANTIVIRAL
SUPPRESS CYTOMEGALOVIRUS (CMV) REPLICATION
CMV DNA POLYMERASE INHIBITOR

ROUTE (list)

INTRAVENOUS

ATC code

J05AB12

PK parameters

VD 26.6 LITER (65 KILOGRAM)
Cl 8.8 LITER / HOUR
PPB 6 PERCENT
t1/2 2.6 HOUR

Solubility

170 MILLIGRAM / MILLILITER IN WATER

Target

TARGET DNA POLYMERASE

PDB
5KM8 (HUMAN HISTIDINE TRIAD NUCLEOTIDE BINDING PROTEIN 2 (HHINT2) CIDOFOVIR COMPLEX)

Ligand code = L8P (link to the list of PDB complexes)

Download experimental 3D coordinates of L8P with added hydrogens

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

[(2S)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethylphosphonic acid

Formula:
C8H14N3O6P

Calculated chemical properties:

MW 277.18
NB_atoms 18
XLogP -2.93
PSA 140.36
NB_HD 3
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 0

FDA
NDA 020638 (pdf not found) INN (CIDOFOVIR) VISTIDE (GILEAD SCIENCES INC) APPROVAL= AP YEAR= 1996 NEWMOLECULARENTITY DISCONTINUED
NDA 201276 (pdf not found) INN (CIDOFOVIR) CIDOFOVIR (MYLAN INSTITUTIONAL) APPROVAL= AP YEAR= 2012
NDA 202501 (pdf not found) INN (CIDOFOVIR) CIDOFOVIR (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2012