e-Drug3D

770

cas 129618-40-2

CLASS

ANTIINFECTIVES
ANTI-HIV AGENTS
NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 93 PERCENT
VD 78.6 LITER (65 KILOGRAM)
Cl 1.17 LITER / HOUR (65 KILOGRAM)
PPB 60 PERCENT
t1/2 45 HOUR

TARGET HIV REVERSE TRANSCRIPTASE (GAG-POL POLYPROTEIN)

PDB
1JLF (CRYSTAL STRUCTURE OF Y188C MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE)

Ligand code = NVP (link to the list of PDB complexes)

Download experimental 3D coordinates of NVP with added hydrogens

MW 266.30
NB_atoms 20
XLogP 2.65
PSA 50.759
NB_HD 1
NB_HA 5
fsp3 0.27
Lipinski(0=no;1=yes) 1

FDA
NDA 020636 (pdf not found) INN (NEVIRAPINE) VIRAMUNE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020933 (pdf not found) INN (NEVIRAPINE) VIRAMUNE (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 021841 (pdf not found) INN (NEVIRAPINE) LAMIVUDINE/ZIDOVUDINE TABLETS CO-PACKAGED WITH NEVIRAPINE TABLETS (PHARMACARE LTD) APPROVAL= TA YEAR= 2005 OBSOLETE
NDA 077429 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (RANBAXY) APPROVAL= TA YEAR= 2005
NDA 021939 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; NEVIRAPINE) LAMIVUDINE, ZIDOVUDINE, NEVIRAPINE TABS 150MG/300MG/200MG (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2006
NDA 021969 (pdf not found) INN (LAMIVUDINE ; STAVUDINE ; NEVIRAPINE) LAMIVUDINE; STAVUDINE; NEVIRAPINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2006
NDA 021971 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; NEVIRAPINE) LAMIVUDINE; ZIDOVUDINE; NEVIRAPINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2007
NDA 021972 (pdf not found) INN (NEVIRAPINE) LAMIVUDINE; STAVUDINE; NEVIRAPINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2007 OBSOLETE
NDA 078887 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (EMCURE PHARMA) APPROVAL= TA YEAR= 2007
NDA 021854 (pdf not found) INN (STAVUDINE ; LAMIVUDINE ; NEVIRAPINE) STAVUDINE; LAMIVUDINE W/NEVIRAPINE (STRIDES ACROLAB) APPROVAL= TA YEAR= 2007
NDA 021988 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; NEVIRAPINE) LAMIVUDINE/ZIDOVUDINE 150 MG/300 MG TABLETS CO-PACKAGED WITH NEVIRAPINE 200 MG TABLETS (STRIDES ACROLAB) APPROVAL= TA YEAR= 2007
NDA 021837 (pdf not found) INN (STAVUDINE ; LAMIVUDINE ; NEVIRAPINE) STAVUDINE; LAMIVUDINE; NEVIRAPINE (STRIDES ARCOLAB) APPROVAL= TA YEAR= 2008
NDA 022177 (pdf not found) INN (STAVUDINE ; LAMIVUDINE ; NEVIRAPINE) STAVUDINE; LAMIVUDINE; NEVIRAPINE (STRIDES ACROLAB) APPROVAL= TA YEAR= 2008
NDA 022061 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE; NEVIRAPINE; ZIDOVUDINE (MATRIX LABS) APPROVAL= TA YEAR= 2008
NDA 022342 (pdf not found) INN (STAVUDINE ; LAMIVUDINE ; NEVIRAPINE) STAVUDINE; LAMIVUDINE; NEVIRAPINE (EMCURE PHARMA) APPROVAL= TA YEAR= 2009
NDA 022346 (pdf not found) INN (STAVUDINE ; LAMIVUDINE ; NEVIRAPINE) STAVUDINE; LAMIVUDINE; NEVIRAPINE (PHARMACARE LTD) APPROVAL= TA YEAR= 2009
NDA 022356 (pdf not found) INN (LAMIVUDINE ; ZIDOVUDINE ; NEVIRAPINE) LAMIVUDINE, ZIDOVUDINE TABS 150MG/300MG CO-PACKAGED WITH NEVIRAPINE TABS 200MG (HETERO DRUGS LTD) APPROVAL= TA YEAR= 2009
NDA 022464 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE; NEVIRAPINE; ZIDOVUDINE (STRIDES ARCOLAB LTD) APPROVAL= TA YEAR= 2009
NDA 022299 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE TABLETS FOR ORAL SUSPENSION (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2010
NDA 022537 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; STAVUDINE) LAMIVUDINE, NEVIRAPINE, AND STAVUDINE (MACLEODS PHARMA) APPROVAL= TA YEAR= 2010
NDA 200244 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; STAVUDINE) LAMIVUDINE, NEVIRAPINE, AND STAVUDINE (HETERO DRUGS LTD) APPROVAL= TA YEAR= 2010
NDA 200793 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE/NEVIRAPINE/ZIDOVUDINE TABLETS (MATRIX LABS) APPROVAL= TA YEAR= 2010
NDA 201152 (pdf not found) INN (NEVIRAPINE) VIRAMUNE XR (BOEHRINGER INGELHEIM) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 202157 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE; NEVIRAPINE; ZIDOVUDINE (HETERO LABS UNIT III) APPROVAL= TA YEAR= 2011
NDA 202171 (pdf not found) INN (LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE ; NEVIRAPINE) LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE; NEVIRAPINE (MATRIX LABS LTD) APPROVAL= TA YEAR= 2011
NDA 077521 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (AUROBINDO) APPROVAL= AP YEAR= 2012
NDA 077702 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (AUROBINDO) APPROVAL= AP YEAR= 2012
NDA 077956 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (CIPLA) APPROVAL= AP YEAR= 2012
NDA 078195 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (STRIDES PHARMA) APPROVAL= AP YEAR= 2012
NDA 078584 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2012
NDA 078644 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (PRINSTON INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 078864 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202523 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (MYLAN PHARMS INC) APPROVAL= AP YEAR= 2012
NDA 202589 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE; NEVIRAPINE; ZIDOVUDINE (MACLEODS PHARMS LTD) APPROVAL= TA YEAR= 2012
NDA 202212 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2012
NDA 202685 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE; NEVIRAPINE; ZIDOVUDINE (STRIDES ARCOLAB LTD) APPROVAL= TA YEAR= 2012
NDA 203021 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (APOTEX INC) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 203076 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE; NEVIRAPINE; ZIDOVUDINE (CIPLA LTD) APPROVAL= TA YEAR= 2012
NDA 203080 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (MICRO LABS LTD) APPROVAL= AP YEAR= 2012
NDA 203176 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (TECH ORGANIZED) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 204505 (pdf not found) INN (LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE ; NEVIRAPINE) LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE; NEVIRAPINE (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2013
NDA 203411 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (SANDOZ) APPROVAL= AP YEAR= 2014
NDA 205258 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (APOTEX) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 205355 (pdf not found) INN (LAMIVUDINE ; TENOFOVIR DISOPROXIL FUMARATE ; NEVIRAPINE) LAMIVUDINE; TENOFOVIR DISOPROXIL FUMARATE; NEVIRAPINE (HETERO LABS LTD III) APPROVAL= TA YEAR= 2014
NDA 205651 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (MYLAN) APPROVAL= AP YEAR= 2014
NDA 205921 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 206042 (pdf not found) INN (EMTRICITABINE ; TENOFOVIR DISOPROXIL FUMARATE ; NEVIRAPINE) EMTRICITABINE;TENOFOVIR DISOPROXIL FUMARATE;NEVIRAPINE (MYLAN LABS LTD) APPROVAL= TA YEAR= 2014
NDA 204621 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (ALVOGEN) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 207064 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (CIPLA LIMITED) APPROVAL= TA YEAR= 2015
NDA 206271 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 206448 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (CIPLA) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 208616 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 207467 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (TECH ORGANIZED) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 207684 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (CIPLA) APPROVAL= AP YEAR= 2017
NDA 207698 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 206879 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 205626 (pdf not found) INN (LAMIVUDINE ; NEVIRAPINE ; ZIDOVUDINE) LAMIVUDINE, NEVIRAPINE AND ZIDOVUDINE (MICRO LABS) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 090688 (pdf not found) INN (NEVIRAPINE) NEVIRAPINE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2019