e-Drug3D

766

PENCICLOVIR

INN
PENCICLOVIR

(is an active metabolite) (has an active metabolite)

cas 39809-25-1

CLASS

ANTIINFECTIVES
ANTIVIRAL
TREATMENT OF HERPES VIRUS HSV-1 AND HSV-2

ROUTE (list)

TOPICAL

ATC code

D06BB06
J05AB13

PK parameters

Tmax 0.7 HOUR
VD 71.5 LITER (65 KILOGRAM)
Cl 32.7 LITER / HOUR (65 KILOGRAM)
PPB 14 PERCENT
t1/2 2.1 HOUR

Solubility

OF 1.7 MILLIGRAM / MILLILITER IN WATER

Target

TARGET THYMIDINE KINASE

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

2-amino-9-[4-hydroxy-3-(hydroxymethyl)butyl]-3H-purin-6-one

Formula:
C10H15N5O3

Calculated chemical properties:

MW 253.27
NB_atoms 18
XLogP -1.31
PSA 120.44
NB_HD 5
NB_HA 8
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 020629 (label) INN (PENCICLOVIR) DENAVIR (MYLAN) APPROVAL= AP YEAR= 1996 NEWMOLECULARENTITY
NDA 212710 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022
NDA 216981 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (TORRENT) APPROVAL= AP YEAR= 2023
NDA 212368 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (PADAGIS ISRAEL) APPROVAL= AP YEAR= 2024
NDA 214100 (pdf not found) INN (PENCICLOVIR) PENCICLOVIR (AMNEAL) APPROVAL= AP YEAR= 2025