e-Drug3D

757

cas 106133-20-4

CLASS

GENITO
BENIGN PROSTATIC HYPERPLASIA (BPH) RELATED TO BLADDER OUTLET OBSTRUCTION
ADRENERGIC (ALPHA-1) BLOCKER

ROUTE (list)

ORAL

PK parameters

F 90 PERCENT
Tmax 5 HOUR
VD 16 LITER
Cl 2.88 LITER / HOUR
PPB 96.5 PERCENT
t1/2 14.9 HOUR

TARGET ALPHA-1A ADRENERGIC RECEPTOR
ALPHA-1B ADRENERGIC RECEPTOR
ALPHA-1D ADRENERGIC RECEPTOR

PDB
7YMJ (CRYO-EM STRUCTURE OF ALPHA1AAR-NB6 COMPLEX BOUND TO TAMSULOSIN)

Ligand code = JGX (link to the list of PDB complexes)

Download experimental 3D coordinates of JGX with added hydrogens

MW 408.51
NB_atoms 28
XLogP 2.34
PSA 101.974
NB_HD 3
NB_HA 7
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 020579 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) FLOMAX (SANOFI) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 077451 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (RANBAXY) APPROVAL= TA YEAR= 2007 OBSOLETE
NDA 077630 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2010
NDA 078015 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2010
NDA 078225 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2010
NDA 022460 (pdf not found) INN (DUTASTERIDE ; TAMSULOSIN HYDROCHLORIDE) JALYN (WAYLIS THERAP) APPROVAL= AP YEAR= 2010
NDA 078801 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (SYNTHON BV) APPROVAL= AP YEAR= 2010
NDA 078938 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2010
NDA 090377 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 2010
NDA 090408 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 090931 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202010 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202433 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2013
NDA 202509 (pdf not found) INN (DUTASTERIDE ; TAMSULOSIN HYDROCHLORIDE) DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (PH HEALTH) APPROVAL= AP YEAR= 2014
NDA 202975 (pdf not found) INN (DUTASTERIDE ; TAMSULOSIN HYDROCHLORIDE) DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204645 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2017
NDA 207405 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2017
NDA 207769 (pdf not found) INN (DUTASTERIDE ; TAMSULOSIN HYDROCHLORIDE) DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2018
NDA 211885 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2019
NDA 214730 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2022
NDA 213300 (pdf not found) INN (DUTASTERIDE ; TAMSULOSIN HYDROCHLORIDE) DUTASTERIDE AND TAMSULOSIN HYDROCHLORIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 219767 (pdf not found) INN (TAMSULOSIN HYDROCHLORIDE) TAMSULOSIN HYDROCHLORIDE (GRAVITI PHARMS) APPROVAL= AP YEAR= 2025