e-Drug3D

755

cas 97682-44-5

CLASS

ANTINEOPLASTIC
TOPOISOMERASE I INHIBITOR
CAMPTOTHECIN DERIVATIVES

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 376 LITER
Cl 22.3 LITER / HOUR
PPB 49 PERCENT
t1/2 8 HOUR

TARGET DNA TOPOISOMERASE I COMPLEX

PDB
1U65 (ACHE W. CPT-11)

Ligand code = CP0 (link to the list of PDB complexes)

Download experimental 3D coordinates of CP0 with added hydrogens

MW 586.67
NB_atoms 43
XLogP 4.09
PSA 108.656
NB_HD 1
NB_HA 10
fsp3 0.52
Lipinski(0=no;1=yes) 0

FDA
NDA 020571 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) CAMPTOSAR (PFIZER INC) APPROVAL= AP YEAR= 1996
NDA 078839 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (APOTEX CORP) APPROVAL= AP YEAR= 2007 OBSOLETE
NDA 077219 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (CIPLA LTD) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 077260 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (TEVA PARENTERAL) APPROVAL= AP YEAR= 2008
NDA 077776 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008
NDA 077915 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2008
NDA 077994 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078188 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078589 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2008
NDA 078796 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2008
NDA 078805 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (SUN PHARMA GLOBAL) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078122 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (PLIVA LACHEMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078753 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008
NDA 079068 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2008
NDA 090101 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2008
NDA 090016 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (HISUN PHARM HANGZHOU) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090137 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090726 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2009
NDA 078953 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091032 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2010
NDA 090393 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (ZENNOVA) APPROVAL= AP YEAR= 2011
NDA 090675 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (HENGRUI PHARMA) APPROVAL= AP YEAR= 2011
NDA 200771 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (EMCURE PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 207793 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) ONIVYDE (IPSEN) APPROVAL= AP YEAR= 2015
NDA 203380 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2016
NDA 206935 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (NOVAST LABS) APPROVAL= AP YEAR= 2017
NDA 203054 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (INTAS PHARMS USA) APPROVAL= AP YEAR= 2017
NDA 208718 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (SHILPA) APPROVAL= AP YEAR= 2018
NDA 212993 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2019
NDA 213278 (pdf not found) INN (IRINOTECAN HYDROCHLORIDE) IRINOTECAN HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2020