e-Drug3D

753

cas 129318-43-0

CLASS

METABOLISM
BONE RESORPTION INHIBITOR
BISPHOSPHONATE
ANTIHYPOCALCEMIC AGENTS
ANTIRESORPTIVES

ROUTE (list)

ORAL

PK parameters

F 0.64 PERCENT
VD 28 LITER
Cl 12 LITER / HOUR
PPB 78 PERCENT
t1/2 87600 HOUR

TARGET FARNESYL PYROPHOSPHATE SYNTHASE

PDB
5DZ2 (GEOSMIN SYNTHASE FROM STREPTOMYCES COELICOLOR N-TERMINAL DOMAIN COMPLEXED WITH THREE MG2+ IONS AND ALENDRONIC ACID)

Ligand code = 212 (link to the list of PDB complexes)

Download experimental 3D coordinates of 212 with added hydrogens

MW 245.06
NB_atoms 14
XLogP -3.80
PSA 156.128
NB_HD 3
NB_HA 8
fsp3 1.00
Lipinski(0=no;1=yes) 0

FDA
NDA 020560 (pdf not found) INN (ALENDRONATE SODIUM) FOSAMAX (ORGANON) APPROVAL= AP YEAR= 1995
NDA 075711 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (IVAX PHARMS) APPROVAL= TA YEAR= 2002 OBSOLETE
NDA 021575 (pdf not found) INN (ALENDRONATE SODIUM) FOSAMAX (MERCK) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 021762 (pdf not found) INN (ALENDRONATE SODIUM ; CHOLECALCIFEROL) FOSAMAX PLUS D (ORGANON LLC) APPROVAL= AP YEAR= 2005
NDA 075710 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (IMPAX LABS INC) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 076184 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (TEVA PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 076584 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (RISING) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 076768 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (CIPLA) APPROVAL= AP YEAR= 2008
NDA 076984 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (WATSON LABS) APPROVAL= AP YEAR= 2008
NDA 077982 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (APOTEX) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078638 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (MYLAN) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 079049 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 079109 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2008 OBSOLETE
NDA 090022 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2008
NDA 090124 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2008
NDA 075871 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (CHARTWELL RX) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090258 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (HANGZHOU BINJIANG) APPROVAL= AP YEAR= 2009
NDA 090557 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (JUBILANT CADISTA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 202344 (pdf not found) INN (ALENDRONATE SODIUM) BINOSTO (RADIUS) APPROVAL= AP YEAR= 2012
NDA 090520 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (HIKMA) APPROVAL= AP YEAR= 2013
NDA 214512 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2023
NDA 206387 (pdf not found) INN (ALENDRONATE SODIUM) ALENDRONATE SODIUM (IPCA LABS LTD) APPROVAL= AP YEAR= 2024