e-Drug3D

747

BUTENAFINE

INN
BUTENAFINE

cas 101828-21-1

CLASS

DERMATOLOGICALS
ANTIFUNGAL
INHIBITING THE EPOXIDATION OF SQUALENE THUS BLOCKING THE BIOSYNTHESIS OF ERGOSTEROL

ROUTE (list)

TOPICAL

ATC code

D01AE23

PK parameters

Tmax 15 HOUR

Solubility

SLIGHTLY SOLUBLE IN WATER

Target

TARGET SQUALENE EPOXIDASE

DrugCentral

Squalene epoxidase UNIPROT Q4JEY0

Download SDF file

1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine

Formula:
C23H27N

Calculated chemical properties:

MW 317.46
NB_atoms 24
XLogP 5.77
PSA 5.671
NB_HD 0
NB_HA 1
fsp3 0.30
Lipinski(0=no;1=yes) 0

FDA
NDA 020524 (pdf not found) INN (BUTENAFINE HYDROCHLORIDE) MENTAX (PHARMOBEDIENT) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 020663 (pdf not found) INN (BUTENAFINE HYDROCHLORIDE) MENTAX (MYLAN BERTEK) APPROVAL= AP YEAR= 1996 NEWAPPLICATION
NDA 021307 (pdf not found) INN (BUTENAFINE HYDROCHLORIDE) LOTRIMIN ULTRA (BAYER HEALTHCARE LLC) APPROVAL= AP YEAR= 2001
NDA 021408 (pdf not found) INN (BUTENAFINE HYDROCHLORIDE) MENTAX-TC (PHARMOBEDIENT) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 205181 (pdf not found) INN (BUTENAFINE HYDROCHLORIDE) BUTENAFINE HYDROCHLORIDE (TARO) APPROVAL= AP YEAR= 2017