e-Drug3D

742

cas 93479-97-1

CLASS

METABOLISM
ANTIDIABETIC
TREATMENT OF TYPE 2 DIABETES MELLITUS
HYPOGLYCEMIC AGENTS
SULFONYLUREAS

ROUTE (list)

ORAL

PK parameters

F 100 PERCENT
Tmax 2.5 HOUR
VD 8.8 LITER
Cl 2.8 LITER / HOUR
PPB 95.5 PERCENT
t1/2 5.08 HOUR

TARGET ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL

PDB
4YVX (CRYSTAL STRUCTURE OF AKR1C3 COMPLEXED WITH GLIMEPIRIDE)

Ligand code = GMR (link to the list of PDB complexes)

Download experimental 3D coordinates of GMR with added hydrogens

MW 490.62
NB_atoms 34
XLogP 3.07
PSA 118.093
NB_HD 3
NB_HA 9
fsp3 0.54
Lipinski(0=no;1=yes) 1

FDA
NDA 020496 (label) INN (GLIMEPIRIDE) AMARYL (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 021700 (label) INN (GLIMEPIRIDE ; ROSIGLITAZONE MALEATE) AVANDARYL (SB PHARMCO) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076802 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (TEVA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076875 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (RANBAXY LABS LTD) APPROVAL= TA YEAR= 2005
NDA 077091 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2005
NDA 077274 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077295 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2005
NDA 077366 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (RANBAXY) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077370 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (PRINSTON INC) APPROVAL= AP YEAR= 2005
NDA 077624 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 021925 (label) INN (GLIMEPIRIDE ; PIOGLITAZONE HYDROCHLORIDE) DUETACT (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 2006
NDA 077280 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (WATSON LABS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077486 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (MYLAN) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 078181 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2007
NDA 077911 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (CARLSBAD) APPROVAL= AP YEAR= 2009
NDA 076995 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091220 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (MICRO LABS) APPROVAL= AP YEAR= 2012
NDA 202759 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2012
NDA 078952 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (HIKMA PHARMS) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 201049 (pdf not found) INN (GLIMEPIRIDE ; PIOGLITAZONE HYDROCHLORIDE) PIOGLITAZONE HYDROCHLORIDE AND GLIMEPIRIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 202112 (pdf not found) INN (GLIMEPIRIDE) GLIMEPIRIDE (INDOCO REMEDIES) APPROVAL= AP YEAR= 2013
NDA 078709 (label) INN (GLIMEPIRIDE ; ROSIGLITAZONE MALEATE) ROSIGLITAZONE MALEATE AND GLIMEPIRIDE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2016 DISCONTINUED