e-Drug3D

736

ZILEUTON

INN
ZILEUTON

cas 111406-87-2

CLASS

ANTIINFLAMMATORY
INHIBITS LEUKOTRIENE SYNTHESIS
5-LIPOXYGENASE INHIBITORS

ROUTE (list)

ORAL

ATC code

PK parameters

Tmax 1.7 HOUR
VD 78 LITER (65 KILOGRAM)
Cl 27.3 LITER / HOUR (65 KILOGRAM)
PPB 93 PERCENT
t1/2 2.5 HOUR

Solubility

PRACTICALLY INSOLUBLE IN WATER

Target

TARGET 5-LIPOXYGENASE

DrugCentral

Arachidonate 5-lipoxygenase UNIPROT P09917 ALOX5

Download SDF file

1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea

Formula:
C11H12N2O2S

Calculated chemical properties:

MW 236.30
NB_atoms 16
XLogP 2.73
PSA 59.385
NB_HD 3
NB_HA 4
fsp3 0.18
Lipinski(0=no;1=yes) 1

FDA
NDA 020471 (pdf not found) INN (ZILEUTON) ZYFLO (CHIESI) APPROVAL= AP YEAR= 1996
NDA 022052 (pdf not found) INN (ZILEUTON) ZYFLO CR (CHIESI) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 204929 (pdf not found) INN (ZILEUTON) ZILEUTON (RISING) APPROVAL= AP YEAR= 2017
NDA 211972 (pdf not found) INN (ZILEUTON) ZILEUTON (LUPIN LTD) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212670 (pdf not found) INN (ZILEUTON) ZILEUTON (STRIDES PHARMA) APPROVAL= AP YEAR= 2019
NDA 211390 (pdf not found) INN (ZILEUTON) ZILEUTON (AIZANT) APPROVAL= AP YEAR= 2020
NDA 211043 (pdf not found) INN (ZILEUTON) ZILEUTON (TEVA PHARMS USA) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 215742 (pdf not found) INN (ZILEUTON) ZILEUTON (ANNORA PHARMA) APPROVAL= AP YEAR= 2022