e-Drug3D

731

cas 123-99-9

CLASS

DERMATOLOGICALS
ANTIMICROBIAL
INHIBITION OF MICROBIAL CELLULAR PROTEIN SYNTHESIS

ROUTE (list)

TOPICAL

PK parameters

F 4 PERCENT
t1/2 0.75 HOUR

TARGET DIAMINOPIMELATE DECARBOXYLASE

PDB
1TUF (CRYSTAL STRUCTURE OF DIAMINOPIMELATE DECARBOXYLASE FROM M. JANNASCHI)

Ligand code = AZ1 (link to the list of PDB complexes)

Download experimental 3D coordinates of AZ1 with added hydrogens

MW 186.20
NB_atoms 13
XLogP -0.78
PSA 71.139
NB_HD 0
NB_HA 4
fsp3 0.78
Lipinski(0=no;1=yes) 1

FDA
NDA 020428 (label) INN (AZELAIC ACID) AZELEX (ALMIRALL) APPROVAL= AP YEAR= 1995
NDA 021470 (label) INN (AZELAIC ACID) FINACEA (LEO PHARMA AS) APPROVAL= AP YEAR= 2002
NDA 207071 (label) INN (AZELAIC ACID) FINACEA (LEO PHARMA AS) APPROVAL= AP YEAR= 2015
NDA 204637 (pdf not found) INN (AZELAIC ACID) AZELAIC ACID (GLENMARK SPECLT) APPROVAL= AP YEAR= 2018
NDA 208011 (pdf not found) INN (AZELAIC ACID) AZELAIC ACID (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2018
NDA 208724 (pdf not found) INN (AZELAIC ACID) AZELAIC ACID (ENCUBE) APPROVAL= AP YEAR= 2018
NDA 210549 (pdf not found) INN (AZELAIC ACID) AZELAIC ACID (TARO) APPROVAL= AP YEAR= 2019
NDA 210928 (pdf not found) INN (AZELAIC ACID) AZELAIC ACID (TEVA PHARMS USA) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 212581 (pdf not found) INN (AZELAIC ACID) AZELAIC ACID (TARO PHARM INDS LTD) APPROVAL= TA YEAR= 2021