e-Drug3D

727

cas 120279-96-1

CLASS

SENSORY
ANTIGLAUCOMA
ANTIHYPERTENSIVE AGENTS
CARBONIC ANHYDRASE INHIBITORS

ROUTE (list)

OPHTHALMIC

PK parameters

PPB 33 PERCENT
t1/2 2880 HOUR

TARGET CARBONIC ANHYDRASE II

PDB
3FW3 (CRYSTAL STRUCTURE OF SOLUBLE DOMAIN OF CA4 IN COMPLEX WITH DORZOLAMIDE)

Ligand code = ETS (link to the list of PDB complexes)

Download experimental 3D coordinates of ETS with added hydrogens

MW 324.46
NB_atoms 19
XLogP 0.61
PSA 109.128
NB_HD 3
NB_HA 6
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
NDA 020408 (label) INN (DORZOLAMIDE HYDROCHLORIDE) TRUSOPT (MSD SUB MERCK) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 020869 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) COSOPT (THEA PHARMA) APPROVAL= AP YEAR= 1998
NDA 077847 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078201 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (RUBICON) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078395 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2008
NDA 077846 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078748 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 078749 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2008
NDA 078756 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (TEVA PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078704 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (TEVA PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078981 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 079186 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (AM REGENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090037 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090143 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (BAUSCH AND LOMB) APPROVAL= AP YEAR= 2009
NDA 090604 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 202667 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) COSOPT PF (THEA PHARMA) APPROVAL= AP YEAR= 2012
NDA 091034 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (ZAMBON SPA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 091180 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ZAMBON SPA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 201998 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202053 (label) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (INDOCO) APPROVAL= AP YEAR= 2014
NDA 202054 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (INDOCO) APPROVAL= AP YEAR= 2014
NDA 203058 (label) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2014
NDA 207630 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2018
NDA 205294 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (FDC LTD) APPROVAL= AP YEAR= 2019
NDA 204778 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (MICRO LABS) APPROVAL= AP YEAR= 2019
NDA 205295 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (FDC LTD) APPROVAL= AP YEAR= 2019
NDA 207523 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (SOMERSET) APPROVAL= AP YEAR= 2019
NDA 212639 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (ALEMBIC) APPROVAL= AP YEAR= 2019
NDA 204777 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2020
NDA 207629 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (EUGIA PHARMA) APPROVAL= AP YEAR= 2021
NDA 213099 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (ALEMBIC) APPROVAL= AP YEAR= 2021
NDA 215660 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (GLAND) APPROVAL= AP YEAR= 2022
NDA 215936 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (MICRO LABS) APPROVAL= AP YEAR= 2022
NDA 215520 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (GLAND PHARMA LTD) APPROVAL= AP YEAR= 2022
NDA 217260 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (INGENUS PHARMS LLC) APPROVAL= AP YEAR= 2023
NDA 215004 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE) DORZOLAMIDE HYDROCHLORIDE (SOMERSET THERAPS LLC) APPROVAL= AP YEAR= 2025
NDA 216308 (pdf not found) INN (DORZOLAMIDE HYDROCHLORIDE ; TIMOLOL MALEATE) DORZOLAMIDE HYDROCHLORIDE AND TIMOLOL MALEATE (NEW HEIGHTSRX) APPROVAL= AP YEAR= 2025