e-Drug3D

724

VINORELBINE


INN
VINORELBINE

cas 71486-22-1
CLASS

ANTINEOPLASTIC
INTERFERES WITH MICROTUBULE ASSEMBLY

ROUTE (list)

INJECTION

ATC code

L01CA04

PK parameters

VD 2128 LITER (65 KILOGRAM)
Cl 72.4 LITER / HOUR (65 KILOGRAM)
PPB 85.4 PERCENT
t1/2 35 HOUR

Solubility

> 1000 MILLIGRAM / MILLILITER IN WATER


Target

TARGET TUBULIN

DrugCentral

Tubulin beta UNIPROT P07437 TUBB

Download SDF file Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,6R,8S)-4-ethyl-1,3,6,7,8,9-hexahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2.beta.,3.beta.,4.beta.,5.alpha.,12R,19.alpha.)-

Formula:
C45H54N4O8

Calculated chemical properties:

MW 778.92
NB_atoms 57
XLogP 4.75
PSA 108.706
NB_HD 2
NB_HA 12
fsp3 0.53
Lipinski(0=no;1=yes) 0

FDA
NDA 020388 (pdf not found) INN (VINORELBINE TARTRATE) NAVELBINE (PIERRE FABRE) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 075992 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 076028 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (TEVA PHARMS USA) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 076461 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 076827 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (HOSPIRA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076849 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 078408 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (EBEWE PHARMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 078011 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2009
NDA 091106 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (JIANGSU HANSOH PHARM) APPROVAL= AP YEAR= 2012
NDA 200148 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (RISING) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202017 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (DR REDDYS) APPROVAL= AP YEAR= 2013
NDA 208997 (pdf not found) INN (VINORELBINE TARTRATE) VINORELBINE TARTRATE (NOVAST LABS) APPROVAL= AP YEAR= 2019 DISCONTINUED

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL