e-Drug3D

717

cas 68475-42-3

CLASS

ANTINEOPLASTIC
REDUCES BLOOD PLATELET COUNT
TREATMENT OF ESSENTIAL-THROMBOCYTHAEMIA (ET)

ROUTE (list)

ORAL

PK parameters

F 70 PERCENT
Tmax 1 HOUR
t1/2 1.5 HOUR

TARGET CYCLIC AMP PHOSPHODIESTERASE III

PDB
7EG0 (CRYO-EM STRUCTURE OF ANAGRELIDE-INDUCED PDE3A-SLFN12 COMPLEX)

Ligand code = J33 (link to the list of PDB complexes)

Download experimental 3D coordinates of J33 with added hydrogens

MW 256.09
NB_atoms 16
XLogP 1.93
PSA 45.405
NB_HD 1
NB_HA 4
fsp3 0.20
Lipinski(0=no;1=yes) 1

FDA
NDA 020333 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) AGRYLIN (TAKEDA PHARMS USA) APPROVAL= AP YEAR= 1997
NDA 076417 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076468 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (CIPLA) APPROVAL= AP YEAR= 2005
NDA 076489 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (ROXANE) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076530 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (BARR LABS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076683 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076811 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (ESJAY PHARMA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 076910 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 2005
NDA 077613 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (RISING) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 209151 (pdf not found) INN (ANAGRELIDE HYDROCHLORIDE) ANAGRELIDE HYDROCHLORIDE (TORRENT) APPROVAL= AP YEAR= 2017