e-Drug3D
715
CARVEDILOL
INN
CARVEDILOL
cas 72956-09-3
CLASS
CARDIOVASCULAR
ANTIHYPERTENSIVE
ANTIANGINAL
ADRENERGIC ALPHA ANTAGONISTS
ADRENERGIC BETA ANTAGONISTS
VASODILATOR AGENTS
ROUTE (list)
ORAL
PK parameters
F 30 PERCENT
VD 115 LITER
Cl 36 LITER / HOUR
PPB 98 PERCENT
t1/2 8.5 HOUR
Solubility
PRATICALLY INSOLUBLE IN WATER
TARGET BETA ADRENERGIC RECEPTOR
ALPHA-1A ADRENERGIC RECEPTOR
Beta-1 adrenergic receptor UNIPROT P08588 ADRB1
Beta-2 adrenergic receptor UNIPROT P07550 ADRB2
Formula:
C24H26N2O4
Calculated chemical properties:
MW 406.47
NB_atoms 30
XLogP 3.74
PSA 81.034
NB_HD 3
NB_HA 6
fsp3 0.25
Lipinski(0=no;1=yes) 1
NB_atoms 30
XLogP 3.74
PSA 81.034
NB_HD 3
NB_HA 6
fsp3 0.25
Lipinski(0=no;1=yes) 1
FDA
NDA 020297 (label) INN (CARVEDILOL) COREG (WAYLIS THERAP) APPROVAL= AP YEAR= 1995
NDA 022012 (label) INN (CARVEDILOL PHOSPHATE) COREG CR (WAYLIS THERAP) APPROVAL= AP YEAR= 2006
NDA 076373 (pdf not found) INN (CARVEDILOL) CARVEDILOL (TEVA) APPROVAL= AP YEAR= 2007
NDA 076649 (pdf not found) INN (CARVEDILOL) CARVEDILOL (GRAVITI PHARMS) APPROVAL= AP YEAR= 2007
NDA 076989 (pdf not found) INN (CARVEDILOL) CARVEDILOL (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077316 (pdf not found) INN (CARVEDILOL) CARVEDILOL (PHARMOBEDIENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077346 (label) INN (CARVEDILOL) CARVEDILOL (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077474 (pdf not found) INN (CARVEDILOL) CARVEDILOL (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2007
NDA 077614 (pdf not found) INN (CARVEDILOL) CARVEDILOL (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2007
NDA 077780 (pdf not found) INN (CARVEDILOL) CARVEDILOL (TARO) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077887 (pdf not found) INN (CARVEDILOL) CARVEDILOL (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078165 (pdf not found) INN (CARVEDILOL) CARVEDILOL (RUBICON RESEARCH) APPROVAL= AP YEAR= 2007
NDA 078217 (pdf not found) INN (CARVEDILOL) CARVEDILOL (LUPIN) APPROVAL= AP YEAR= 2007
NDA 078227 (pdf not found) INN (CARVEDILOL) CARVEDILOL (SANDOZ) APPROVAL= AP YEAR= 2007
NDA 078240 (pdf not found) INN (CARVEDILOL) CARVEDILOL (PLIVA HRVATSKA DOO) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078251 (pdf not found) INN (CARVEDILOL) CARVEDILOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2007
NDA 078332 (pdf not found) INN (CARVEDILOL) CARVEDILOL (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007
NDA 078384 (pdf not found) INN (CARVEDILOL) CARVEDILOL (BEXIMCO USA) APPROVAL= AP YEAR= 2007
NDA 078786 (pdf not found) INN (CARVEDILOL) CARVEDILOL (MLV) APPROVAL= AP YEAR= 2009
NDA 090132 (pdf not found) INN (CARVEDILOL PHOSPHATE) CARVEDILOL PHOSPHATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2017
NDA 204717 (pdf not found) INN (CARVEDILOL PHOSPHATE) CARVEDILOL PHOSPHATE (IMPAX LABS INC) APPROVAL= AP YEAR= 2018
NDA 020297 (label) INN (CARVEDILOL) COREG (WAYLIS THERAP) APPROVAL= AP YEAR= 1995
NDA 022012 (label) INN (CARVEDILOL PHOSPHATE) COREG CR (WAYLIS THERAP) APPROVAL= AP YEAR= 2006
NDA 076373 (pdf not found) INN (CARVEDILOL) CARVEDILOL (TEVA) APPROVAL= AP YEAR= 2007
NDA 076649 (pdf not found) INN (CARVEDILOL) CARVEDILOL (GRAVITI PHARMS) APPROVAL= AP YEAR= 2007
NDA 076989 (pdf not found) INN (CARVEDILOL) CARVEDILOL (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077316 (pdf not found) INN (CARVEDILOL) CARVEDILOL (PHARMOBEDIENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077346 (label) INN (CARVEDILOL) CARVEDILOL (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077474 (pdf not found) INN (CARVEDILOL) CARVEDILOL (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2007
NDA 077614 (pdf not found) INN (CARVEDILOL) CARVEDILOL (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2007
NDA 077780 (pdf not found) INN (CARVEDILOL) CARVEDILOL (TARO) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077887 (pdf not found) INN (CARVEDILOL) CARVEDILOL (HIKMA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078165 (pdf not found) INN (CARVEDILOL) CARVEDILOL (RUBICON RESEARCH) APPROVAL= AP YEAR= 2007
NDA 078217 (pdf not found) INN (CARVEDILOL) CARVEDILOL (LUPIN) APPROVAL= AP YEAR= 2007
NDA 078227 (pdf not found) INN (CARVEDILOL) CARVEDILOL (SANDOZ) APPROVAL= AP YEAR= 2007
NDA 078240 (pdf not found) INN (CARVEDILOL) CARVEDILOL (PLIVA HRVATSKA DOO) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078251 (pdf not found) INN (CARVEDILOL) CARVEDILOL (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2007
NDA 078332 (pdf not found) INN (CARVEDILOL) CARVEDILOL (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007
NDA 078384 (pdf not found) INN (CARVEDILOL) CARVEDILOL (BEXIMCO USA) APPROVAL= AP YEAR= 2007
NDA 078786 (pdf not found) INN (CARVEDILOL) CARVEDILOL (MLV) APPROVAL= AP YEAR= 2009
NDA 090132 (pdf not found) INN (CARVEDILOL PHOSPHATE) CARVEDILOL PHOSPHATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2017
NDA 204717 (pdf not found) INN (CARVEDILOL PHOSPHATE) CARVEDILOL PHOSPHATE (IMPAX LABS INC) APPROVAL= AP YEAR= 2018