e-Drug3D

712

cas 33069-62-4

CLASS

ANTINEOPLASTIC
TUBULIN MODULATORS
STABILIZES MICROTUBULES BY PREVENTING DEPOLYMERIZATION

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 736 LITER
Cl 19.6 LITER / HOUR
PPB 93 PERCENT
t1/2 20.2 HOUR

TARGET TUBULIN

PDB
4AQW (MODEL OF HUMAN KINESIN-5 MOTOR DOMAIN (1II6, 3HQD) AND MAMMALIAN TUBULIN HETERODIMER (1JFF) DOCKED INTO THE 9.5-ANGSTROM CRYO-EM MAP OF MICROTUBULE-BOUND KINESIN-5 MOTOR DOMAIN IN THE RIGOR STATE.)

Ligand code = TA1 (link to the list of PDB complexes)

Download experimental 3D coordinates of TA1 with added hydrogens

MW 853.89
NB_atoms 62
XLogP 3.74
PSA 188.242
NB_HD 4
NB_HA 15
fsp3 0.45
Lipinski(0=no;1=yes) 0

FDA
NDA 020262 (pdf not found) INN (PACLITAXEL) TAXOL (HQ SPCLT PHARMA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 075184 (pdf not found) INN (PACLITAXEL) PACLITAXEL (TEVA PHARMS) APPROVAL= AP YEAR= 2002
NDA 075190 (pdf not found) INN (PACLITAXEL) PACLITAXEL (HIKMA) APPROVAL= AP YEAR= 2002
NDA 075278 (pdf not found) INN (PACLITAXEL) PACLITAXEL (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075297 (pdf not found) INN (PACLITAXEL) PACLITAXEL (TEVA PHARMS USA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076131 (pdf not found) INN (PACLITAXEL) PACLITAXEL (HOSPIRA) APPROVAL= AP YEAR= 2002
NDA 076233 (pdf not found) INN (PACLITAXEL) PACLITAXEL (HOSPIRA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075436 (pdf not found) INN (PACLITAXEL) PACLITAXEL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021660 (pdf not found) INN (PACLITAXEL) ABRAXANE (BRISTOL-MYERS) APPROVAL= AP YEAR= 2005
NDA 077574 (pdf not found) INN (PACLITAXEL) PACLITAXEL (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2006
NDA 078167 (pdf not found) INN (PACLITAXEL) PACLITAXEL (SANDOZ) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077413 (pdf not found) INN (PACLITAXEL) PACLITAXEL (PLIVA LACHEMA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 090130 (pdf not found) INN (PACLITAXEL) PACLITAXEL (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2009
NDA 091540 (pdf not found) INN (PACLITAXEL) PACLITAXEL (DASH PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 207326 (pdf not found) INN (PACLITAXEL) PACLITAXEL (GLAND) APPROVAL= AP YEAR= 2016
NDA 205720 (pdf not found) INN (PACLITAXEL) PACLITAXEL (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2018
NDA 213434 (pdf not found) INN (PACLITAXEL) PACLITAXEL (MSN) APPROVAL= AP YEAR= 2020
NDA 211875 (pdf not found) INN (PACLITAXEL) PACLITAXEL (AM REGENT) APPROVAL= AP YEAR= 2022
NDA 216874 (pdf not found) INN (PACLITAXEL) PACLITAXEL (ALEMBIC) APPROVAL= AP YEAR= 2022
NDA 216338 (pdf not found) INN (PACLITAXEL) PACLITAXEL (TEVA PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 212700 (pdf not found) INN (PACLITAXEL) PACLITAXEL (HENGRUI PHARMA) APPROVAL= AP YEAR= 2024
NDA 209657 (pdf not found) INN (PACLITAXEL) PACLITAXEL (CIPLA) APPROVAL= AP YEAR= 2025
NDA 216355 (pdf not found) INN (PACLITAXEL) PACLITAXEL (SHUANGCHENG) APPROVAL= AP YEAR= 2025
NDA 217877 (pdf not found) INN (PACLITAXEL) PACLITAXEL (MYLAN) APPROVAL= AP YEAR= 2025