e-Drug3D

708

cas 54739-18-3

CLASS

NERVOUS SYSTEM
ANTIOBSESSIONAL AGENT
ANTIDEPRESSANT
ANTI-ANXIETY AGENTS
SELECTIVE SEROTONIN REUPTAKE INHIBITORS (SSRIS)

ROUTE (list)

ORAL

PK parameters

F 53 PERCENT
Tmax 5.5 HOUR
VD 1625 LITER (65 KILOGRAM)
Cl 72 LITER / HOUR (EQN)
PPB 80 PERCENT
t1/2 15.6 HOUR

TARGET SEROTONIN TRANSPORTER (SERT)

PDB
6AWP (X-RAY STRUCTURE OF THE TS3 HUMAN SEROTONIN TRANSPORTER COMPLEXED WITH FLUVOXAMINE AT THE CENTRAL SITE)

Ligand code = FVX (link to the list of PDB complexes)

Download experimental 3D coordinates of FVX with added hydrogens

MW 318.34
NB_atoms 22
XLogP 3.20
PSA 56.949
NB_HD 2
NB_HA 4
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 020243 (pdf not found) INN (FLUVOXAMINE MALEATE) LUVOX (SOLVAY) APPROVAL= AP YEAR= 1994 NEWMOLECULARENTITY DISCONTINUED
NDA 075888 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (AIPING PHARM INC) APPROVAL= AP YEAR= 2000
NDA 075889 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075901 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075887 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (UPSHER SMITH LABS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075894 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (HERITAGE PHARMA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075897 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075898 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (ANI PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075899 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (SYNTHON PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075902 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (APOTEX) APPROVAL= AP YEAR= 2001
NDA 075950 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (MYLAN) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075893 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (TEVA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076125 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075900 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (CHARTWELL RX) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 021519 (pdf not found) INN (FLUVOXAMINE MALEATE) LUVOX (ANI PHARMS) APPROVAL= AP YEAR= 2007
NDA 022033 (pdf not found) INN (FLUVOXAMINE MALEATE) LUVOX CR (JAZZ PHARMS) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 022235 (pdf not found) INN (FLUVOXAMINE MALEATE) LUVOX (JAZZ) APPROVAL= AP YEAR= 2008 NEWAPPLICATION
NDA 091476 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (PH HEALTH) APPROVAL= AP YEAR= 2013
NDA 091482 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2013
NDA 203240 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (TORRENT) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 212182 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (BIONPHARMA) APPROVAL= AP YEAR= 2020
NDA 217917 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (BIONPHARMA) APPROVAL= AP YEAR= 2024
NDA 219055 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 217024 (pdf not found) INN (FLUVOXAMINE MALEATE) FLUVOXAMINE MALEATE (ANNORA PHARMA) APPROVAL= AP YEAR= 2025