e-Drug3D

707

cas 84057-84-1

CLASS

NERVOUS SYSTEM
ANTICONVULSANT
ANTIEPILEPTIC
PHENYLTRIAZINE CLASS
TREATMENT OF BIPOLAR I DISORDER
SODIUM CHANNEL BLOCKER

ROUTE (list)

ORAL

PK parameters

F 98 PERCENT
Tmax 1.7 HOUR
VD 71.5 LITER (65 KILOGRAM)
Cl 2.2 LITER / HOUR (65 KILOGRAM)
PPB 55 PERCENT
t1/2 25.4 HOUR

TARGET VOLTAGE-SENSITIVE SODIUM CHANNEL

PDB
8THH (CRYO-EM STRUCTURE OF NAV1.7 WITH LTG)

Ligand code = IYJ (link to the list of PDB complexes)

Download experimental 3D coordinates of IYJ with added hydrogens

MW 256.10
NB_atoms 16
XLogP 2.01
PSA 79.122
NB_HD 4
NB_HA 5
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 020241 (pdf not found) INN (LAMOTRIGINE) LAMICTAL (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 1994
NDA 020764 (pdf not found) INN (LAMOTRIGINE) LAMICTAL CD (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 1998
NDA 076388 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (TEVA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076420 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (TEVA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077392 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ROXANE) APPROVAL= TA YEAR= 2006
NDA 077757 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (CARACO) APPROVAL= TA YEAR= 2007
NDA 076630 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 076701 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2009
NDA 076708 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2009
NDA 076928 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (WATSON LABS) APPROVAL= AP YEAR= 2009
NDA 077420 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (RISING) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077428 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (NATCO PHARMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077633 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ZYDUS PHARMS USA) APPROVAL= AP YEAR= 2009
NDA 078009 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2009
NDA 078409 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (CHARTWELL RX) APPROVAL= AP YEAR= 2009
NDA 078443 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078525 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (TARO PHARM INDS) APPROVAL= AP YEAR= 2009
NDA 078645 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (AIPING PHARM INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 022115 (pdf not found) INN (LAMOTRIGINE) LAMICTAL XR (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 2009
NDA 022251 (pdf not found) INN (LAMOTRIGINE) LAMICTAL ODT (GLAXOSMITHKLINE LLC) APPROVAL= AP YEAR= 2009
NDA 078310 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ZENNOVA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078625 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2009
NDA 078947 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (TORRENT PHARMS) APPROVAL= AP YEAR= 2009
NDA 078956 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009
NDA 078982 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (GRANULES) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 079099 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2009
NDA 079132 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (JUBILANT CADISTA) APPROVAL= AP YEAR= 2009
NDA 079204 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (TARO) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090401 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009
NDA 077783 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 022509 (pdf not found) INN (LAMOTRIGINE) LAMICTAL XR (SMITHKLINE BEECHAM) APPROVAL= AP YEAR= 2010
NDA 078691 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (LUPIN LTD) APPROVAL= AP YEAR= 2010
NDA 078134 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (HIKMA PHARMS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 078669 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090607 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ALEMBIC PHARMS LTD) APPROVAL= AP YEAR= 2011
NDA 200220 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090170 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (UNICHEM LABS LTD) APPROVAL= AP YEAR= 2011
NDA 090169 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2012
NDA 201374 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (PH HEALTH) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 200672 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2013
NDA 200694 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2013
NDA 200828 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (IMPAX LABS INC) APPROVAL= AP YEAR= 2013
NDA 201791 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (PH HEALTH) APPROVAL= AP YEAR= 2013
NDA 202383 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2013
NDA 202498 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2013
NDA 202887 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2013
NDA 203370 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (TORRENT) APPROVAL= AP YEAR= 2013
NDA 203733 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2013 OBSOLETE
NDA 201168 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ALEMBIC) APPROVAL= AP YEAR= 2014
NDA 204158 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (PH HEALTH) APPROVAL= AP YEAR= 2015
NDA 206382 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (SCIEGEN PHARMS INC) APPROVAL= AP YEAR= 2016
NDA 207497 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2018
NDA 207763 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2020
NDA 213271 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2021
NDA 213949 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (YILING) APPROVAL= AP YEAR= 2021
NDA 214124 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (AMRING PHARMS) APPROVAL= AP YEAR= 2022
NDA 204499 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (IPCA LABS) APPROVAL= AP YEAR= 2024
NDA 211821 (pdf not found) INN (LAMOTRIGINE) LAMOTRIGINE (ALEMBIC) APPROVAL= AP YEAR= 2024