e-Drug3D

701

CLADRIBINE

INN
CLADRIBINE

(has an active metabolite)

cas 4291-63-8

CLASS

ANTINEOPLASTIC
IMMUNOSUPPRESSIVE AGENTS
TREATMENT OF HAIRY CELL LEUKEMIA

ROUTE (list)

INJECTION ORAL

ATC code

L01BB04
L04AA40

PK parameters

VD 292.5 LITER (65 KILOGRAM)
Cl 63.5 LITER / HOUR (65 KILOGRAM)
PPB 20 PERCENT
t1/2 5.4 HOUR

Target

TARGET DEOXYCYTIDINE KINASE

PDB
2ZIA (C4S DCK VARIANT OF DCK IN COMPLEX WITH CLADRIBINE+UDP)

Ligand code = CL9 (link to the list of PDB complexes)

Download experimental 3D coordinates of CL9 with added hydrogens

DrugCentral

Unknown

Download SDF file

(2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol

Formula:
C10H12ClN5O3

Calculated chemical properties:

MW 285.70
NB_atoms 19
XLogP -0.30
PSA 113.129
NB_HD 4
NB_HA 8
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 020229 (pdf not found) INN (CLADRIBINE) LEUSTATIN (JANSSEN PHARMS) APPROVAL= AP YEAR= 1993 NEWMOLECULARENTITY DISCONTINUED
NDA 075405 (pdf not found) INN (CLADRIBINE) CLADRIBINE (HIKMA) APPROVAL= AP YEAR= 2000
NDA 076571 (pdf not found) INN (CLADRIBINE) CLADRIBINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2004
NDA 200510 (pdf not found) INN (CLADRIBINE) CLADRIBINE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 022561 (pdf not found) INN (CLADRIBINE) MAVENCLAD (EMD SERONO INC) APPROVAL= AP YEAR= 2019
NDA 210856 (pdf not found) INN (CLADRIBINE) CLADRIBINE (HISUN PHARM HANGZHOU) APPROVAL= AP YEAR= 2019