e-Drug3D
696
CISAPRIDE
DISCONTINUED
INN
CISAPRIDE
cas 81098-60-4
CLASS
METABOLISM
GASTROINTESTINAL AGENTS
TREATMENT OF NOCTURNAL HEARTBURN DUE TO GASTROESOPHAGEAL REFLUX DISEASE
SEROTONIN RECEPTOR 5-HT4 AGONIST
ROUTE (list)
ORAL
ATC code
A03FA02
PK parameters
F 37.5 PERCENT
Tmax 1.25 HOUR
VD 180 LITER
Cl 6 LITER / HOUR
PPB 98 PERCENT
t1/2 4 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET 5-HYDROXYTRYPTAMINE 4 RECEPTOR
5-hydroxytryptamine receptor 4 UNIPROT Q13639 HTR4
Formula:
C23H29ClFN3O4
Calculated chemical properties:
MW 465.94
NB_atoms 32
XLogP 3.36
PSA 86.366
NB_HD 3
NB_HA 7
fsp3 0.43
Lipinski(0=no;1=yes) 1
NB_atoms 32
XLogP 3.36
PSA 86.366
NB_HD 3
NB_HA 7
fsp3 0.43
Lipinski(0=no;1=yes) 1
FDA
NDA 020210 (pdf not found) INN (CISAPRIDE MONOHYDRATE) PROPULSID (JANSSEN PHARMS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020398 (pdf not found) INN (CISAPRIDE MONOHYDRATE) PROPULSID (JANSSEN PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020767 (pdf not found) INN (CISAPRIDE MONOHYDRATE) PROPULSID QUICKSOLV (JANSSEN PHARMA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 020210 (pdf not found) INN (CISAPRIDE MONOHYDRATE) PROPULSID (JANSSEN PHARMS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 020398 (pdf not found) INN (CISAPRIDE MONOHYDRATE) PROPULSID (JANSSEN PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 020767 (pdf not found) INN (CISAPRIDE MONOHYDRATE) PROPULSID QUICKSOLV (JANSSEN PHARMA) APPROVAL= AP YEAR= 1997 DISCONTINUED