e-Drug3D

691

cas 98319-26-7

CLASS

DERMATOLOGICALS
ANTI-BALDNESS AGENTS
5 ALPHA REDUCTASE INHIBITORS

ROUTE (list)

ORAL

PK parameters

F 63 PERCENT
Tmax 1.5 HOUR
VD 76 LITER
Cl 9.9 LITER / HOUR
PPB 90 PERCENT
t1/2 6 HOUR

TARGET 5-ALPHA DEHYDROGENASE

PDB
3G1R (CRYSTAL STRUCTURE OF HUMAN LIVER 5BETA-REDUCTASE (AKR1D1) IN COMPLEX WITH NADP AND FINASTERIDE. RESOLUTION 1.70 A)

Ligand code = FIT (link to the list of PDB complexes)

Download experimental 3D coordinates of FIT with added hydrogens

MW 372.54
NB_atoms 27
XLogP 3.81
PSA 54.522
NB_HD 2
NB_HA 4
fsp3 0.83
Lipinski(0=no;1=yes) 1

FDA
NDA 020180 (label) INN (FINASTERIDE) PROSCAR (ORGANON) APPROVAL= AP YEAR= 1992
NDA 020788 (label) INN (FINASTERIDE) PROPECIA (ORGANON) APPROVAL= AP YEAR= 1997
NDA 076340 (pdf not found) INN (FINASTERIDE) FINASTERIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076436 (pdf not found) INN (FINASTERIDE) FINASTERIDE (DR REDDYS LABS INC) APPROVAL= AP YEAR= 2006
NDA 076511 (pdf not found) INN (FINASTERIDE) FINASTERIDE (TEVA) APPROVAL= AP YEAR= 2006
NDA 077251 (pdf not found) INN (FINASTERIDE) FINASTERIDE (GEDEON RICHTER USA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077578 (pdf not found) INN (FINASTERIDE) FINASTERIDE (MYLAN) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 076437 (pdf not found) INN (FINASTERIDE) FINASTERIDE (DR REDDYS LABS LTD) APPROVAL= AP YEAR= 2007
NDA 077914 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ACTAVIS TOTOWA TEVA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078341 (pdf not found) INN (FINASTERIDE) FINASTERIDE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2007
NDA 078900 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ZYDUS PHARMS USA INC) APPROVAL= AP YEAR= 2009
NDA 090121 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2010
NDA 090061 (pdf not found) INN (FINASTERIDE) FINASTERIDE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2010
NDA 090507 (pdf not found) INN (FINASTERIDE) FINASTERIDE (SUN PHARM) APPROVAL= AP YEAR= 2011
NDA 076905 (pdf not found) INN (FINASTERIDE) FINASTERIDE (TEVA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 078371 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 090060 (pdf not found) INN (FINASTERIDE) FINASTERIDE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2013
NDA 091643 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2013
NDA 090508 (pdf not found) INN (FINASTERIDE) FINASTERIDE (SUN PHARM) APPROVAL= AP YEAR= 2013
NDA 203687 (pdf not found) INN (FINASTERIDE) FINASTERIDE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2013
NDA 078161 (pdf not found) INN (FINASTERIDE) FINASTERIDE (NATCO PHARMA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 077335 (pdf not found) INN (FINASTERIDE) FINASTERIDE (CIPLA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 204304 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2017
NDA 207750 (pdf not found) INN (FINASTERIDE) FINASTERIDE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2017
NDA 215423 (label) INN (FINASTERIDE ; TADALAFIL) ENTADFI (BLUE WATER BIOTECH) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 218232 (pdf not found) INN (FINASTERIDE ; TADALAFIL) FINASTERIDE AND TADALAFIL (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2024 DISCONTINUED
NDA 218499 (pdf not found) INN (FINASTERIDE ; TADALAFIL) FINASTERIDE AND TADALAFIL (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2025