e-Drug3D

689

ALATROFLOXACIN

DISCONTINUED

INN
ALATROFLOXACIN

(has an active metabolite)

cas 146961-76-4

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
FLUOROQUINOLONE

ROUTE (list)

INJECTION

ATC code

J01MA13

PK parameters

Target

TARGET DNA GYRASE SUBUNIT A
DNA TOPOISOMERASE 4 SUBUNIT A
DNA TOPOISOMERASE 2-ALPHA

DrugCentral

Topoisomerase IV UNIPROT P0AFI2 parC

DNA gyrase UNIPROT P0AES4 gyrA

Download SDF file

L-Alaninamide, L-alanyl-N-[(1.alpha.,5.alpha.,6.alpha.)-3-[6-carboxy-8-(2,4-difluorophenyl)-3-fluoro-5,8-dihydro-5-oxo-1,8-naphthyridin-2-yl]-3-azabicyclo[3.1.0]hex-6-yl]-

Formula:
C26H25F3N6O5

Calculated chemical properties:

MW 557.51
NB_atoms 40
XLogP -0.43
PSA 147.083
NB_HD 4
NB_HA 11
fsp3 0.35
Lipinski(0=no;1=yes) 0

FDA
NDA 020760 (pdf not found) INN (ALATROFLOXACIN MESYLATE) TROVAN PRESERVATIVE FREE (PFIZER) APPROVAL= AP YEAR= 1997 NEWMOLECULARENTITY DISCONTINUED