e-Drug3D

683

PENTOSTATIN

INN
PENTOSTATIN

cas 53910-25-1

CLASS

ANTINEOPLASTIC
IMMUNOSUPPRESSIVE AGENTS
TREATMENT OF LEUKAEMIA

ROUTE (list)

INJECTION

ATC code

L01XX08

PK parameters

VD 37 LITER (PMID12172976)
Cl 6.5 LITER / HOUR (PMID12172976)
PPB 3.8 PERCENT (PMID12172976)
t1/2 6 HOUR (PMID12172976)

Target

TARGET ADENOSINE DEAMINASE

DrugCentral

Adenosine deaminase UNIPROT P00813 ADA

Download SDF file

(8R)-3-[4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-7,8-dihydro-4H-imidazo[4,5-f][1,3]diazepin-8-ol

Formula:
C11H16N4O4

Calculated chemical properties:

MW 268.28
NB_atoms 19
XLogP -0.99
PSA 110.744
NB_HD 4
NB_HA 8
fsp3 0.64
Lipinski(0=no;1=yes) 1

FDA
NDA 020122 (pdf not found) INN (PENTOSTATIN) NIPENT (HOSPIRA INC) APPROVAL= AP YEAR= 1991
NDA 077841 (pdf not found) INN (PENTOSTATIN) PENTOSTATIN (WEST-WARD PHARMS INT) APPROVAL= AP YEAR= 2007
NDA 203554 (pdf not found) INN (PENTOSTATIN) PENTOSTATIN (RISING) APPROVAL= AP YEAR= 2014 DISCONTINUED