e-Drug3D

682

TENIPOSIDE

DISCONTINUED

INN
TENIPOSIDE

cas 29767-20-2

CLASS

ANTINEOPLASTIC
CYTOTOXIC
NUCLEIC ACID SYNTHESIS INHIBITORS

ROUTE (list)

INJECTION

ATC code

L01CB02

PK parameters

VD 41 LITER
Cl 0.99 LITER / HOUR
PPB 99 PERCENT
t1/2 5 HOUR

Solubility

INSOLUBLE IN WATER

Target

TARGET DNA TOPOISOMERASE 2

PDB
4L9Q (X-RAY STUDY OF HUMAN SERUM ALBUMIN COMPLEXED WITH TENIPOSIDE)

Ligand code = 9TP (link to the list of PDB complexes)

Download experimental 3D coordinates of 9TP with added hydrogens

DrugCentral

DNA topoisomerase 2-alpha UNIPROT P11388 TOP2A

Download SDF file

Furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one, 5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)-9-[[4,6-O-[(R)-2-thienylmethylene]-.beta.-D-glucopyranosyl]oxy]-, (5R,5aR,8aR,9S)-

Formula:
C32H32O13S

Calculated chemical properties:

MW 656.65
NB_atoms 46
XLogP 2.75
PSA 173.137
NB_HD 3
NB_HA 13
fsp3 0.47
Lipinski(0=no;1=yes) 0

FDA
NDA 020119 (pdf not found) INN (TENIPOSIDE) VUMON (HQ SPECLT PHARMA) APPROVAL= AP YEAR= 1992 DISCONTINUED