e-Drug3D
677
FLUMAZENIL
INN
FLUMAZENIL
cas 78755-81-4
CLASS
VARIOUS
BENZODIAZEPINE ANTAGONIST
ANTIDOTES
GABA ANATAGONIST
ROUTE (list)
INJECTION
ATC code
V03AB25
PK parameters
VD 65 LITER (65 KILOGRAM)
Cl 58.5 LITER / HOUR (65 KILOGRAM)
PPB 50 PERCENT
t1/2 1 HOUR
Solubility
INSOLUBLE IN WATER
TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR
PDB
6D6T (HUMAN GABA-A RECEPTOR ALPHA1-BETA2-GAMMA2 SUBTYPE IN COMPLEX WITH GABA AND FLUMAZENIL, CONFORMATION B)
Ligand code = FYP (link to the list of PDB complexes)
Download experimental 3D coordinates of FYP with added hydrogens
Gamma-aminobutyric acid receptor subunit alpha-4 UNIPROT P48169 GABRA4
GABA-A receptor alpha-2,beta-3,gamma-2 UNIPROT P18507 GABRG2
Formula:
C15H14FN3O3
Calculated chemical properties:
MW 303.29
NB_atoms 22
XLogP 1.77
PSA 57.446
NB_HD 0
NB_HA 6
fsp3 0.27
Lipinski(0=no;1=yes) 1
NB_atoms 22
XLogP 1.77
PSA 57.446
NB_HD 0
NB_HA 6
fsp3 0.27
Lipinski(0=no;1=yes) 1
FDA
NDA 020073 (label) INN (FLUMAZENIL) ROMAZICON (HOFFMANN LA ROCHE) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 076256 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076589 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (DR REDDYS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076755 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2004
NDA 076787 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076955 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2004
NDA 077071 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 078595 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (RISING) APPROVAL= AP YEAR= 2008
NDA 078527 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2009
NDA 090584 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (SAGENT PHARMS) APPROVAL= AP YEAR= 2012
NDA 020073 (label) INN (FLUMAZENIL) ROMAZICON (HOFFMANN LA ROCHE) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY DISCONTINUED
NDA 076256 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076589 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (DR REDDYS) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 076755 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2004
NDA 076787 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (HIKMA) APPROVAL= AP YEAR= 2004
NDA 076955 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2004
NDA 077071 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 078595 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (RISING) APPROVAL= AP YEAR= 2008
NDA 078527 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (HIKMA FARMACEUTICA) APPROVAL= AP YEAR= 2009
NDA 090584 (pdf not found) INN (FLUMAZENIL) FLUMAZENIL (SAGENT PHARMS) APPROVAL= AP YEAR= 2012