e-Drug3D

675

TACRINE

DISCONTINUED

INN
TACRINE

cas 321-64-2

CLASS

NERVOUS SYSTEM
ANTICHOLINESTERASE
CHOLINESTERASE INHIBITOR

ROUTE (list)

ORAL

ATC code

N06DA01

PK parameters

F 17 PERCENT
Tmax 1.5 HOUR
VD 349 LITER
Cl 218 LITER / HOUR (65 KILOGRAM)
PPB 55 PERCENT
t1/2 3 HOUR

Solubility

FREELY SOLUBLE IN DISTILLED WATER

Target

TARGET CHOLINESTERASE

PDB
2AOW (HISTAMINE METHYLTRANSFERASE (NATURAL VARIANT I105) COMPLEXED WITH THE ACETYLCHOLINESTERASE INHIBITOR AND ALTZHEIMER'S DISEASE DRUG TACRINE)

Ligand code = THA (link to the list of PDB complexes)

Download experimental 3D coordinates of THA with added hydrogens

DrugCentral

Acetylcholinesterase UNIPROT P22303 ACHE

Cholinesterase UNIPROT P06276 BCHE

Download SDF file

1,2,3,4-tetrahydroacridin-9-amine

Formula:
C13H14N2

Calculated chemical properties:

MW 198.26
NB_atoms 15
XLogP 2.70
PSA 31.017
NB_HD 2
NB_HA 2
fsp3 0.31
Lipinski(0=no;1=yes) 1

FDA
NDA 020070 (pdf not found) INN (TACRINE HYDROCHLORIDE) COGNEX (SHIONOGI INC) APPROVAL= AP YEAR= 1993 NEWMOLECULARENTITY DISCONTINUED