e-Drug3D

674

cas 4428-95-9

CLASS

ANTIINFECTIVES
ANTIVIRAL
CHELATE DIVALENT METAL IONS
INHIBITS REPLICATION OF HERPES VIRUSES CMV, HSV-1 AND HSV-2

ROUTE (list)

INJECTION

PK parameters

VD 33.8 LITER (65 KILOGRAM)
Cl 7.1 LITER / HOUR
PPB 16 PERCENT
t1/2 3.3 HOUR

TARGET DNA POLYMERASE

PDB
1NKI (CRYSTAL STRUCTURE OF THE FOSFOMYCIN RESISTANCE PROTEIN A (FOSA) CONTAINING BOUND PHOSPHONOFORMATE)

Ligand code = PPF (link to the list of PDB complexes)

Download experimental 3D coordinates of PPF with added hydrogens

MW 122.98
NB_atoms 7
XLogP -2.76
PSA 94.318
NB_HD 0
NB_HA 5
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 020068 (pdf not found) INN (FOSCARNET SODIUM) FOSCAVIR (CLINIGEN HLTHCARE) APPROVAL= AP YEAR= 1991 NEWMOLECULARENTITY
NDA 077174 (pdf not found) INN (FOSCARNET SODIUM) FOSCARNET SODIUM (HOSPIRA) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 212483 (pdf not found) INN (FOSCARNET SODIUM) FOSCARNET SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2021
NDA 213001 (pdf not found) INN (FOSCARNET SODIUM) FOSCARNET SODIUM (GLAND) APPROVAL= AP YEAR= 2021
NDA 213807 (pdf not found) INN (FOSCARNET SODIUM) FOSCARNET SODIUM (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2023
NDA 213987 (pdf not found) INN (FOSCARNET SODIUM) FOSCARNET SODIUM (SCIECURE) APPROVAL= AP YEAR= 2023
NDA 216602 (pdf not found) INN (FOSCARNET SODIUM) FOSCARNET SODIUM (AMNEAL) APPROVAL= AP YEAR= 2024