e-Drug3D

SULFANILAMIDE

DISCONTINUED

INN
SULFANILAMIDE

cas 63-74-1

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
SULFONAMIDE ANCHORS ARE COORDINATED TO THE ACTIVE SITE METAL ION OF THE ZINC ENZYME CARBONIC ANHYDRASE (CA, EC 4.2.1.1) (PMID17251017)

ROUTE (list)

VAGINAL

ATC code

D06BA05
J01EB06

PK parameters

Target

TARGET CARBONIC ANHYDRASE

PDB
4COQ (THE COMPLEX OF ALPHA-CARBONIC ANHYDRASE FROM THERMOVIBRIO AMMONIFICANS WITH INHIBITOR SULFANILAMIDE)

Ligand code = SAN (link to the list of PDB complexes)

Download experimental 3D coordinates of SAN with added hydrogens

DrugCentral

Dihydropteroate synthase UNIPROT P0AC13 folP

Download SDF file

4-aminobenzenesulfonamide

Formula:
C6H8N2O2S

Calculated chemical properties:

MW 172.21
NB_atoms 11
XLogP -0.08
PSA 84.485
NB_HD 4
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 006530 (pdf not found) INN (SULFANILAMIDE) AVC (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1965 DISCONTINUED
NDA 088718 (pdf not found) INN (SULFANILAMIDE) SULFANILAMIDE (COSETTE) APPROVAL= AP YEAR= 1985 DISCONTINUED