e-Drug3D

662

cas 66722-44-9

CLASS

CARDIOVASCULAR
ANTIHYPERTENSIVE
ADRENERGIC BETA-1 ANTAGONIST
SYMPATHOLYTICS
ADRENERGIC BETA-2 INVERSE AGONIST

ROUTE (list)

ORAL

PK parameters

F 80 PERCENT
Tmax 3 HOUR
VD 156 LITER (65 KILOGRAM)
Cl 14.4 LITER / HOUR (65 KILOGRAM)
PPB 30 PERCENT
t1/2 10 HOUR

MW 325.44
NB_atoms 23
XLogP 2.37
PSA 67.057
NB_HD 2
NB_HA 5
fsp3 0.67
Lipinski(0=no;1=yes) 1

FDA
NDA 019982 (label) INN (BISOPROLOL FUMARATE) ZEBETA (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1992 NEWMOLECULARENTITY DISCONTINUED
NDA 020186 (label) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) ZIAC (TEVA BRANDED PHARM) APPROVAL= AP YEAR= 1993
NDA 075469 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075527 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075579 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2000
NDA 075632 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075642 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (APOTHECON) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075643 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (RUBICON RESEARCH) APPROVAL= AP YEAR= 2000
NDA 075672 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075768 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (MYLAN) APPROVAL= AP YEAR= 2000
NDA 075644 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (TEVA PHARMS) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075686 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (TEVA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075474 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (TRUPHARMA) APPROVAL= AP YEAR= 2002
NDA 075831 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (DASH PHARMS NATCO) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077910 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2006
NDA 078635 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (UNICHEM) APPROVAL= AP YEAR= 2009
NDA 079106 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (UNICHEM) APPROVAL= AP YEAR= 2010
NDA 204891 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (ALEMBIC) APPROVAL= AP YEAR= 2017
NDA 212678 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (EDENBRIDGE PHARMS) APPROVAL= AP YEAR= 2020
NDA 215562 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2021
NDA 215563 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2021
NDA 215995 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2022
NDA 215666 (pdf not found) INN (BISOPROLOL FUMARATE ; HYDROCHLOROTHIAZIDE) BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE (CADILA) APPROVAL= AP YEAR= 2022
NDA 215680 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2022
NDA 217368 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (PRINSTON INC) APPROVAL= AP YEAR= 2023
NDA 217617 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (HARMAN FINOCHEM) APPROVAL= AP YEAR= 2024
NDA 219044 (pdf not found) INN (BISOPROLOL FUMARATE) BISOPROLOL FUMARATE (UNIQUE PHARM) APPROVAL= AP YEAR= 2025